{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:37:18Z","timestamp":1765294638261},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T00:00:00Z","timestamp":1392336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Crohn's disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) is a painful chronic inflammatory bowel disease. It primarily affects terminal ileum, but the involvement of large and small intestines or extraintestinal manifestations is very common. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> may go along with neurogenic inflammation, mediated by substance P and <jats:styled-content style=\"fixed-case\">CGRP<\/jats:styled-content>, which are also key players in pain transmission. This may in turn contribute to hyperalgesia and altered somatosensory function in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and three (103) patients with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> and 80 healthy volunteers were enrolled. Patient characteristics and disease history were documented. We used quantitative sensory testing (<jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content>) to investigate the somatosensory profile in patients and volunteers. We also calculated <jats:italic>z<\/jats:italic>\u2010scores for the <jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content> results of the patients with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> based on the data of our control group. A 2\u2010step cluster analysis, using all <jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content> data, was performed to find subgroups within patients and volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thresholds of warm detection, mechanical pain, and vibration detection did significantly differ between patients with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> and volunteers. <jats:italic>Z<\/jats:italic>\u2010scores indicated a general trend of sensory loss in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients with a significant relationship between patients with a sensory loss for cold and warm detection. In the hyposensitive cluster of the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> cohort, patients were more frequently male, had a higher incidence of extraintestinal manifestations, and suffered longer from <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings are consistent with the presence of a subclinical small fiber neuropathy. The group of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients with pronounced neuropathy findings were predominantly males, had a higher incidence of extraintestinal manifestations, and tended to have a longer history of disease duration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12182","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T10:05:34Z","timestamp":1392631534000},"page":"265-271","source":"Crossref","is-referenced-by-count":7,"title":["Characterization of Somatosensory Profiles in Patients with Crohn's Disease"],"prefix":"10.1111","volume":"15","author":[{"given":"Tino","family":"M\u00fcnster","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Friedrich\u2010Alexander Universit\u00e4t Erlangen\u2010Nuremberg Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Eckl","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Friedrich\u2010Alexander Universit\u00e4t Erlangen\u2010Nuremberg Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Leis","sequence":"additional","affiliation":[{"name":"Department of Neurology Christian Doppler Klink Paracelsus Medical University Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"G\u00f6hring\u2010Waldeck","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Friedrich\u2010Alexander Universit\u00e4t Erlangen\u2010Nuremberg Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Ihmsen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Friedrich\u2010Alexander Universit\u00e4t Erlangen\u2010Nuremberg Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Maih\u00f6fner","sequence":"additional","affiliation":[{"name":"Department of Neurology Friedrich\u2010Alexander University Erlangen\u2010Nuremberg Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.09.001"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31821fbd82"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.05.002"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.11.009"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.08.010"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.041"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.3.416"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199706000-00005"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20304"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529109025034"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21802"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjgastroenterol.2003.11.001"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040857"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh429"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01718.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000193463"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpapr.12182","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.12182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T21:44:30Z","timestamp":1696283070000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.12182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,14]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/papr.12182"],"URL":"https:\/\/doi.org\/10.1111\/papr.12182","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,14]]}}}