{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:58:50Z","timestamp":1788872330896,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T00:00:00Z","timestamp":1393459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Janssen","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n While the economic costs of pain have been documented, the impact of noncancer pain on quality of life has not been studied extensively.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To estimate the influence of noncancer pain on quality of life measures.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Prospective, multicenter, observational nonrandomized patient pain registry.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Outpatient settings.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n Patients with acute episodes of noncancer pain requiring treatment with a prescription medication containing oxycodone immediate\u2010release on an as\u2010needed basis for at least 5\u00a0days (\n n<\/jats:italic>\n \u00a0=\u00a0629).\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n The modified Brief Pain Inventory and the 12\u2010item Short Form Health Survey (\n SF<\/jats:styled-content>\n \u201012) was measured at baseline when oxycodone immediate\u2010release began and days 7, 14, 21, and 28. Repeated measures mixed models provided estimates of impact of pain on the physical component summary score (\n PCS<\/jats:styled-content>\n ) and mental health component summary score (\n MCS<\/jats:styled-content>\n ) of the\n SF<\/jats:styled-content>\n \u201012.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Patterns indicating pain oscillation over the 28\u2010day window were common (Range: 44.3% back\/neck pain cohort to 61.2% postoperative cohort). After adjustment for sociodemographics, concomitant medications and gastrointestinal symptoms, worst pain in 24\u00a0hours was associated with a 13.9 point\n PCS<\/jats:styled-content>\n reduction (adjusted\n PCS<\/jats:styled-content>\n for pain\u00a0=\u00a010: 31.1; adjusted\n PCS<\/jats:styled-content>\n for pain\u00a0=\u00a00: 45.0) and a 7.2 point\n MCS<\/jats:styled-content>\n reduction (adjusted\n MCS<\/jats:styled-content>\n for pain\u00a0=\u00a010: 44.1; adjusted\n MCS<\/jats:styled-content>\n for pain\u00a0=\u00a00: 51.3). Similar clinically relevant differences were observed among patients with arthritis, back\/neck pain, injury\/trauma, postoperative pain, neuropathic pain and fibromyalgia, although statistical significance was not observed in the latter 2 groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Among outpatients with various underlying causes of pain, the negative impact of pain on physical and mental health\u2010related quality of life is significant.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/papr.12184","type":"journal-article","created":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T02:53:02Z","timestamp":1393469582000},"page":"333-342","source":"Crossref","is-referenced-by-count":16,"title":["Impact of Noncancer Pain on Health\u2010Related Quality of Life"],"prefix":"10.1111","volume":"15","author":[{"given":"Kate L.","family":"Lapane","sequence":"first","affiliation":[{"name":"Department of Quantitative Health Sciences University of Massachusetts Medical School Worcester Massachusetts U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Quilliam","sequence":"additional","affiliation":[{"name":"College of Pharmacy University of Rhode Island Kingston Rhode Island U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Benson","sequence":"additional","affiliation":[{"name":"Janssen Scientific Affairs LLC Raritan New Jersey U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing","family":"Chow","sequence":"additional","affiliation":[{"name":"Janssen Scientific Affairs LLC Raritan New Jersey U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoung S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Janssen Scientific Affairs LLC Raritan New Jersey 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