{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:24:47Z","timestamp":1792787087990,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:00:00Z","timestamp":1398038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Gr\u00fcnenthal Pharma, S.A"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The present epidemiological research evaluated the prevalence of neuropathic pain characteristics in patients with painful knee osteoarthritis (\n                      <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                      ) and the plausibility that such neuropathic features were specific of\n                      <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Outpatients with chronic pain associated with knee\n                      <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                      who attended orthopedic surgery or rehabilitation clinics were systematically screened for neuropathic pain with the\n                      <jats:italic>Douleur Neuropathique in 4 questions<\/jats:italic>\n                      (\n                      <jats:styled-content style=\"fixed-case\">DN<\/jats:styled-content>\n                      4) questionnaire. Data from medical files and those obtained during a single structured clinical interview were correlated with the\n                      <jats:styled-content style=\"fixed-case\">DN<\/jats:styled-content>\n                      4 scores. Information on potential confounders of neuropathic\u2010like qualities of knee pain was collected to evaluate as much as possible only the symptoms attributable to\n                      <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 2,776 patients recruited, 2,167 patients provided valid data from 2,992 knees. The\n                      <jats:styled-content style=\"fixed-case\">DN<\/jats:styled-content>\n                      4 was scored positively (\u2265\u00a04) in 1,125 patients (51.9%) and 1,459 knees (48.8%). When patients with potential confounders were excluded, the respective prevalences were 33.3% and 29.4%. Patients who scored positively in the\n                      <jats:styled-content style=\"fixed-case\">DN<\/jats:styled-content>\n                      4 had more severe pain, greater structural damage, and more potential confounders of neuropathic pain. Three potential confounders conveyed much of the variability explained by regression analyses. However, latent class analyses revealed that the concourse of other factors is required to explain the neuropathic pain qualities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      A relevant proportion of patients with chronic pain associated with knee\n                      <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                      featured neuropathic pain qualities that were not explained by other conditions. The present research has provided reasonable epidemiological grounds to attempt their definite diagnosis and classification.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/papr.12220","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T03:39:00Z","timestamp":1398051540000},"page":"618-626","source":"Crossref","is-referenced-by-count":34,"title":["High Prevalence of Neuropathic Pain Features in Patients with Knee Osteoarthritis: A Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"15","author":[{"given":"\u00c1ngel","family":"Oteo\u2010\u00c1lvaro","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery and Traumatology Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Ruiz\u2010Ib\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Traumatology Hospital Universitario Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xoan","family":"Miguens","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Hospital de Monforte de Lemos Lugo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Stern","sequence":"additional","affiliation":[{"name":"Department of Medical Gr\u00fcnenthal Pharma S.A. 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