{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:26:31Z","timestamp":1767983191802,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T00:00:00Z","timestamp":1411776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this trial was to determine risk factors for chronic saphenous neuralgia (<jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content>) following harvesting of the great saphenous vein (<jats:styled-content style=\"fixed-case\">GSV<\/jats:styled-content>) for coronary artery bypass graft (<jats:styled-content style=\"fixed-case\">CABG<\/jats:styled-content>) surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective observational trial, 526 patients with no history of chronic painful disorders or surgery in the lower limbs were followed up for 13\u00a0weeks after undergoing <jats:styled-content style=\"fixed-case\">CABG<\/jats:styled-content> surgery in which <jats:styled-content style=\"fixed-case\">GSV<\/jats:styled-content> grafts were used. The primary outcome measure was persistence of clinically significant pain of neuropathic type in the territory supplied by the saphenous nerve beyond 12\u00a0weeks after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010one (15.4%) patients consistently had probable neuropathic pain of clinically significant severity throughout the follow\u2010up period and were labeled as suffering from chronic <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content>. Multivariable binary logistic regression analysis showed that younger age (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 0.92; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.88\u20130.95; <jats:italic>P<\/jats:italic>\u2010value, &lt;\u00a00.0001), female gender (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 2.28; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.21\u20134.29; <jats:italic>P<\/jats:italic>\u2010value, 0.011), higher body mass index (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.25; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.17\u20131.35; <jats:italic>P<\/jats:italic>\u2010value, &lt;\u00a00.0001), diabetes mellitus (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 2.13; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.13\u20134.01; <jats:italic>P<\/jats:italic>\u2010value, 0.020), distal\u2010to\u2010proximal dissection of the <jats:styled-content style=\"fixed-case\">GSV<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 7.28; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 3.62\u201314.66; <jats:italic>P<\/jats:italic>\u2010value, &lt;\u00a00.0001), and closure of the leg wound in two layers (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 3.28; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.81\u20135.95; <jats:italic>P<\/jats:italic>\u2010value, 0.0001) were independent risk factors for chronic <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chronic <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">CABG<\/jats:styled-content> surgery utilizing <jats:styled-content style=\"fixed-case\">GSV<\/jats:styled-content> grafts is not uncommon. Risk factors identified in this trial are younger age, female gender, higher body mass index, diabetes mellitus, distal\u2010to\u2010proximal dissection of the <jats:styled-content style=\"fixed-case\">GSV<\/jats:styled-content>, and closure of the leg wound in two layers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12246","type":"journal-article","created":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T04:27:28Z","timestamp":1411792048000},"page":"720-729","source":"Crossref","is-referenced-by-count":5,"title":["Risk Factors for Chronic Saphenous Neuralgia Following Coronary Artery Bypass Graft Surgery Utilizing Saphenous Vein Grafts"],"prefix":"10.1111","volume":"15","author":[{"given":"Sameh M.","family":"Hakim","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Faculty of Medicine Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer N.","family":"Narouze","sequence":"additional","affiliation":[{"name":"Center for Pain Medicine Summa Western Reserve Hospital Cuyahoga Falls Ohio U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.551"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.08.064"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000136998.39371.FF"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.43.1.41"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(99)00294-8"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199503000-00035"},{"key":"e_1_2_5_8_1","first-page":"121","article-title":"Saphenous neuropathy following coronary bypass","volume":"8","author":"Schnall B","year":"1979","journal-title":"Orthopedic Rev."},{"key":"e_1_2_5_9_1","first-page":"222","article-title":"Sauhenous neurouathv following coronary artery bypass surgery","volume":"81","author":"Chauhan BM","year":"1981","journal-title":"NY State J Med."},{"key":"e_1_2_5_10_1","first-page":"231","article-title":"The course of the distal saphenous nerve: a cadaveric investigation and clinical implications","volume":"31","author":"Mercer D","year":"2011","journal-title":"Iowa Orthop J."},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.11.032"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197911000-00008"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(03)00017-4"},{"key":"e_1_2_5_14_1","first-page":"274","article-title":"Anatomy of the saphenous nerve: relevance to the saphenous vein stripping","volume":"53","author":"Ramasastry SS","year":"1987","journal-title":"Am Surgeon."},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.11.020"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000282763.29778.59"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(90)91158-F"},{"key":"e_1_2_5_18_1","volume-title":"Regression Methods in Biostatistics: Linear, Logistic, Survival, and Repeated Measures Models","author":"Vittinghoff E","year":"2004"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115101"},{"key":"e_1_2_5_20_1","first-page":"631","article-title":"The anatomic relationship between the long saphenous vein and the saphenous nerve. Relevance for radical varicose vein surgery","volume":"154","author":"Holme JB","year":"1988","journal-title":"Acta Chir Scand."},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00076-7"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1323.2001.01828.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)02680-7"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2003.43"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2012.62.1.40"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200301000-00019"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200101000-00001"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005950170196"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/110241501750070583"},{"key":"e_1_2_5_30_1","volume-title":"Classification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms","author":"Merskey H","year":"1994"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.02.018"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e3182411048"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.09.012"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00482-6"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.12.010"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.02969.x"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198509263131306"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-3-199302010-00009"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpapr.12246","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.12246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T22:55:51Z","timestamp":1696287351000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.12246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,27]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/papr.12246"],"URL":"https:\/\/doi.org\/10.1111\/papr.12246","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,27]]}}}