{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:06:01Z","timestamp":1779145561703,"version":"3.51.4"},"reference-count":101,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T00:00:00Z","timestamp":1417564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013132","name":"Mundipharma Pte Ltd","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013132","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cancer pain is prevalent, undertreated, and feared by patients with cancer. In <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pril 2013, a panel of pain experts convened in Singapore to address the treatment of cancer pain. They discussed the various types of cancer pain, including breakthrough pain, which is sometimes clinically confused with analgesic gaps. Reasons for undertreating cancer pain include attitudes of patients, clinicians, and factors associated with healthcare systems. The consequences of not treating cancer pain may include reduced quality of life for patients with cancer (who now live longer than ever), functional decline, and increased psychological stress. Early analgesic intervention for cancer pain may reduce the risk of central sensitization and chronification of pain. To manage pain in oncology patients, clinicians should assess pain during regular follow\u2010up visits using validated pain measurement tools and follow prescribing guidelines, if necessary referring patients with cancer to pain specialists. Many patients with cancer require opioids for pain relief. Pain associated with cancer may also relate to cancer treatments, such as chemotherapy\u2010induced peripheral neuropathy. Many patients with cancer are what might be considered \u201cspecial populations,\u201d in that they may be elderly, frail, comorbid, or have end\u2010stage organ failure. Specific pain therapy guidelines for those populations are reviewed. Patients with cancer with a history of or active substance abuse disorder deserve pain control but may require close medical supervision. While much \u201ctreatment inertia\u201d exists in cancer pain control, cancer pain can be safely and effectively managed and should be carried out to alleviate suffering and improve outcomes.<\/jats:p>","DOI":"10.1111\/papr.12253","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T22:26:26Z","timestamp":1417645586000},"page":"778-792","source":"Crossref","is-referenced-by-count":39,"title":["Treatment Considerations for Cancer Pain: A\u00a0Global Perspective"],"prefix":"10.1111","volume":"15","author":[{"given":"Joseph V.","family":"Pergolizzi","sequence":"first","affiliation":[{"name":"Department of Medicine Johns Hopkins School of Medicine Baltimore Maryland U.S.A"},{"name":"Association of Chronic Pain Patients Houston Texas U.S.A"},{"name":"Department of Pharmacology Temple University School of Medicine Philadelphia Pennsylvania U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Gharibo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine New York University School of Medicine New York City New York U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kok\u2010Yuen","family":"Ho","sequence":"additional","affiliation":[{"name":"Raffles Pain Management Centre Raffles Hospital Singapore City Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,3]]},"reference":[{"key":"e_1_2_14_2_1","unstructured":"World Health Organization.Cancer.Media Center;2013. Fact Sheet No. 297.http:\/\/www.who.int\/mediacentre\/factsheets\/fs297\/en\/(accessed August 8 2013)."},{"key":"e_1_2_14_3_1","unstructured":"International Association for the Study of Pain.Global Year Against Cancer Pain;2009.http:\/\/www.iasp-pain.org\/AM\/Template.cfm?Section=Contact_Us3&Template=\/customsource\/ContactUs\/ContactUs.cfm(accessed August 7 2013)."},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12040"},{"issue":"11","key":"e_1_2_14_5_1","first-page":"S21","article-title":"Pharmacological management of cancer pain","volume":"105","author":"Pharo G","year":"2005","journal-title":"J Am Osteopath Assoc"},{"key":"e_1_2_14_6_1","doi-asserted-by":"crossref","first-page":"iv132","DOI":"10.1093\/annonc\/mdi922","article-title":"World Health Organization guidelines for cancer pain: a reappraisal","volume":"4","author":"Mercadante S","year":"2005","journal-title":"Ann Oncol"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp001"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2006.12.005"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn419"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2006.01.008"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02527837"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.10.028"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0b013e3283434515"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00006-8"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos203"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31827eb5e6"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199403033300902"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.2381"},{"key":"e_1_2_14_19_1","volume-title":"Pain Assessment and Cancer Pain Syndromes","author":"Cherny N","year":"2010"},{"key":"e_1_2_14_20_1","volume-title":"Pathophysiology of Pain in Cancer and Other Terminal Illnesses","author":"Gordon\u2010Williams R","year":"2010"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32836336ad"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2012.03.009"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199305010-00004"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00572091"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0885-3924(91)90518-9"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2013.0211"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12036"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds233"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70380-7"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2012.00602.x"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hys155"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2012.0099"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-012-0831-1"},{"key":"e_1_2_14_34_1","unstructured":"American Pain Society.Guideline for the Management of Cancer Pain in Adults and Children;2004.http:\/\/apps.americanpainsociety.org\/Default.aspx?TabID=251&ProductId=472. (accessed August 10 2013)."},{"key":"e_1_2_14_35_1","volume-title":"NCCN Guidelines and Derivative Information Products: User Guide","author":"National Comprehensive Cancer Network","year":"2013"},{"key":"e_1_2_14_36_1","unstructured":"American Society of Clinical Oncology.Guidelines;2013;http:\/\/www.asco.org\/institute-quality\/guidelines. (accessed August 10 2013)."},{"key":"e_1_2_14_37_1","unstructured":"World Health Organization.WHO's Pain Ladder for Adults;1988.http:\/\/www.who.int\/cancer\/palliative\/painladder\/en\/(accessed May 7 2013)."},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jep.12014"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990902920731"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12040"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70040-2"},{"key":"e_1_2_14_42_1","unstructured":"FDA.Acetaminophen Toxicity. Drug Safety and Availability;2013.http:\/\/www.fda.gov\/drugs\/drugsafety\/ucm230396.htm(accessed September 1 2013)."},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2140"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2010.08.010"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-005-0843-2"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2012.571"},{"key":"e_1_2_14_47_1","first-page":"2408","article-title":"Opioids in people with cancer\u2010related pain","volume":"2008","author":"Quigley C","year":"2008","journal-title":"Clin Evid (Online)"},{"key":"e_1_2_14_48_1","doi-asserted-by":"crossref","first-page":"ES39","DOI":"10.36076\/ppj.2012\/15\/ES39","article-title":"A systematic review of randomized trials on the effectiveness of opioids for cancer pain","volume":"3","author":"Koyyalagunta D","year":"2012","journal-title":"Pain Physician"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269216311418869"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2013.752460"},{"key":"e_1_2_14_51_1","first-page":"435","article-title":"Toxic peripheral neuropathy associated with commonly used chemotherapeutic agents","volume":"15","author":"Argyriou AA","year":"2010","journal-title":"J BUON"},{"key":"e_1_2_14_52_1","volume-title":"Chemotherapy\u2010Induced Peripheral Neuropathy: Review of Clinical Studies","author":"LeQuang J","year":"2012"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2013.05.017"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2013.06.016"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2009.11.018"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2012.00891.x"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2010-0433"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2011000300023"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2008.00204.x"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2009.02376.x"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-010-0118-6"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.5055\/jom.2012.0113"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2010.03.012"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0b013e328336289c"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2009.11.010"},{"key":"e_1_2_14_66_1","first-page":"353","article-title":"Oncological patients' decision\u2010making processes concerning their pain medication at home: a qualitative secondary analysis","volume":"25","author":"Luscher\u2010Buffet C","year":"2012","journal-title":"Pflege"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318241fd07"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005200000176"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2008.04.014"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.NCC.0000305706.91787.8e"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.01.007"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.0561"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1155\/2004\/748685"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suponc.2010.10.006"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmpt.2013.05.021"},{"key":"e_1_2_14_76_1","first-page":"139","article-title":"The Faces Pain Scale for the self\u2010assessment of the severity of pain experienced by children: development, initial validation and preliminary investigation for ratio scale properties","volume":"41","author":"Bieri D","year":"1990","journal-title":"Pain Manage Nurs"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2011.12.010"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2011.01290.x"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200003000-00005"},{"key":"e_1_2_14_80_1","first-page":"711","article-title":"The measurement of pain in intensive care unit: comparison of 5 self\u2010report intensity scales","volume":"151","author":"Chanques G","year":"2010","journal-title":"Pain Manage Nurs"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002820-199704000-00002"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.12.008"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200011150-00017"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(99)71225-9"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2001.tb01132.x"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.1998.tb02667.x"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.4037\/ccn2013804"},{"key":"e_1_2_14_88_1","first-page":"59","article-title":"Sensitivity and specificity of the Critical\u2010Care Pain Observation Tool for the detection of pain in intubated adults after cardiac surgery","volume":"37","author":"Gelinais C","year":"2009","journal-title":"J Pain Symptom Manage"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmn.2009.05.002"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2010.00378.x"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2002.37216"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.5055\/jom.2007.0019"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079908X253708"},{"key":"e_1_2_14_94_1","first-page":"3","article-title":"Pain relievers: bad for your heart? People with heart disease should avoid prolonged use of certain anti\u2010inflammatory drugs, Naproxen (Aleve) is safest","volume":"17","year":"2013","journal-title":"Harv Mens Health Watch"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suponc.2012.05.002"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-012-0274-7"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328360f6f8"},{"key":"e_1_2_14_98_1","first-page":"189","article-title":"Cardiovascular effects of common analgesics","volume":"68","author":"Ong HT","year":"2013","journal-title":"Med J Malaysia"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2000.03290.x"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.10.1247"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S33112"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1521-0391.2013.12043.x"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpapr.12253","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.12253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T22:56:30Z","timestamp":1696287390000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.12253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,3]]},"references-count":101,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/papr.12253"],"URL":"https:\/\/doi.org\/10.1111\/papr.12253","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,3]]}}}