{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:00:13Z","timestamp":1790398813924,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T00:00:00Z","timestamp":1421020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01 HL078536"],"award-info":[{"award-number":["1R01 HL078536"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1U54 HL090513"],"award-info":[{"award-number":["1U54 HL090513"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Pain is the hallmark symptom of sickle cell disease (<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>), yet the types of pain that these patients experience, and the underlying mechanisms, have not been well characterized. The study purpose was to determine the safety and utility of a mechanical and thermal quantitative sensory testing (<jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content>) protocol and the feasibility of utilizing neuropathic pain questionnaires among adults with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A convenience sample (<jats:italic>N<\/jats:italic>\u00a0=\u00a025, 18 women, mean age 38.5\u00a0\u00b1\u00a012.5 [20\u201358\u00a0years]) completed self\u2010report pain and quality\u2010of\u2010life tools. Subjects also underwent testing with the <jats:styled-content style=\"fixed-case\">TSA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> NeuroSensory Analyzer and calibrated von Frey microfilaments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that the <jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content> protocol was safe and did not stimulate a <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> pain crisis. There was evidence of central sensitization (<jats:italic>n<\/jats:italic>\u00a0=\u00a015), peripheral sensitization (<jats:italic>n<\/jats:italic>\u00a0=\u00a01), a mix of central and peripheral sensitization (<jats:italic>n<\/jats:italic>\u00a0=\u00a08), or no sensitization (<jats:italic>n<\/jats:italic>\u00a0=\u00a01). The neuropathic pain self\u2010report tools were feasible with evidence of construct validity; 40% of the subjects reported S\u2010<jats:styled-content style=\"fixed-case\">LANSS<\/jats:styled-content> scores that were indicative of neuropathic pain and had evidence of central, peripheral or mixed sensitization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content> protocol can be safely conducted in adults with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> and provides evidence of central or peripheral sensitization, which is consistent with a neuropathic component to <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> pain. These findings are novel, warrant a larger confirmatory study, and indicate the need for normative <jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content> data from African American adults and older adults.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12279","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T12:05:15Z","timestamp":1421064315000},"page":"282-293","source":"Crossref","is-referenced-by-count":71,"title":["Safety and Utility of Quantitative Sensory Testing among Adults with Sickle Cell Disease: Indicators of Neuropathic Pain?"],"prefix":"10.1111","volume":"16","author":[{"given":"Miriam O.","family":"Ezenwa","sequence":"first","affiliation":[{"name":"University of Illinois at Chicago College of Nursing Department of Biobehavioral Health Science Chicago Illinois U.S.A"},{"name":"University of Illinois at Chicago Comprehensive Sickle Cell Center Chicago Illinois 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Chicago Center of Excellence for End\u2010of\u2010Life Transition Research Chicago Illinois U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie L.","family":"Suarez","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago College of Nursing Department of Biobehavioral Health Science Chicago Illinois U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherese","family":"Pullum","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago College of Nursing Department of Biobehavioral Health Science Chicago Illinois U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith M.","family":"Schlaeger","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago College of Nursing Department of Biobehavioral Health Science Chicago Illinois U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger 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