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Based on the screener and physician evaluation, mutually exclusive groups of subjects without CWP<\/jats:styled-content> (CWP<\/jats:styled-content>\u2212), with CWP<\/jats:styled-content> but without FM<\/jats:styled-content> (CWP<\/jats:styled-content>+), and with confirmed FM<\/jats:styled-content> were identified.<\/jats:p><\/jats:sec>Results<\/jats:title>Disease burden was examined in 472 subjects (125 CWP<\/jats:styled-content>\u2010, 176 CWP<\/jats:styled-content>+, 171 FM<\/jats:styled-content>). Age, race, and ethnicity were similar across groups. Mean body mass index and number of comorbidities increased from CWP<\/jats:styled-content>\u2212 to CWP<\/jats:styled-content>+ to FM<\/jats:styled-content> (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.0044, P\u00a0<\u00a0<\/jats:italic>0.0001, respectively). From CWP<\/jats:styled-content>\u2212 to CWP<\/jats:styled-content>+ to FM<\/jats:styled-content>, there were reductions in health status (EQ<\/jats:styled-content>\u20105D, SF<\/jats:styled-content>\u201012) and sleep outcomes (MOS<\/jats:styled-content>\u2010SS<\/jats:styled-content>, SSQ<\/jats:styled-content>) (all P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05). Pain severity, interference with function (BPI<\/jats:styled-content>\u2010SF<\/jats:styled-content>), and overall work impairment (WPAI<\/jats:styled-content>:SHP<\/jats:styled-content>) increased from CWP<\/jats:styled-content>\u2212 to CWP<\/jats:styled-content>+ to FM<\/jats:styled-content> (all P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.0001). Higher proportions of CWP<\/jats:styled-content>+ (52.8%) and FM<\/jats:styled-content> subjects (62.6%) were taking pain\u2010related prescription medications relative to CWP<\/jats:styled-content>\u2212 subjects (32.8%; P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.0001). Significant differences in total direct and indirect costs across the three groups (both P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.0001) were observed, with highest costs among FM<\/jats:styled-content> subjects.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Fibromyalgia subjects were characterized by the greatest disease burden with more comorbidities and pain\u2010related medications, poorer health status, function, sleep, lower productivity, and higher costs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12302","type":"journal-article","created":{"date-parts":[[2015,5,16]],"date-time":"2015-05-16T08:32:55Z","timestamp":1431765175000},"page":"565-579","source":"Crossref","is-referenced-by-count":78,"title":["The Comparative Burden of Chronic Widespread Pain and Fibromyalgia in the United States"],"prefix":"10.1111","volume":"16","author":[{"given":"Caroline","family":"Schaefer","sequence":"first","affiliation":[{"name":"Covance Market Access Services Inc Gaithersburg MD 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