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In many patients with central sensitization, <jats:styled-content style=\"fixed-case\">CPM<\/jats:styled-content> is less efficacious. Besides that, efficacy of <jats:styled-content style=\"fixed-case\">CPM<\/jats:styled-content> is highly variable in healthy people. Consequently, it seems that several individual variables may influence <jats:styled-content style=\"fixed-case\">CPM<\/jats:styled-content>. A systematic review examining personal factors influencing <jats:styled-content style=\"fixed-case\">CPM<\/jats:styled-content> was conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This systematic review follows the <jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content> guidelines. \u201cPubmed\u201d and \u201cWeb of Science\u201d were searched using different synonyms of <jats:styled-content style=\"fixed-case\">CPM<\/jats:styled-content>. Full\u2010text clinical reports addressing the influence of personal factors on <jats:styled-content style=\"fixed-case\">CPM<\/jats:styled-content> in healthy adults were included. Checklists for <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s and case\u2013control studies provided by the Dutch Institute for Healthcare Improvement (<jats:styled-content style=\"fixed-case\">CBO<\/jats:styled-content>) and the Dutch Cochrane Centre were utilized to assess methodological quality. Levels of evidence and strength of conclusion were assigned using the <jats:styled-content style=\"fixed-case\">CBO<\/jats:styled-content> guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six articles were identified that reported the influence of personal factors on <jats:styled-content style=\"fixed-case\">CPM<\/jats:styled-content>. Quality assessment revealed 10 studies with a methodological quality less than 50% wherefore they were excluded (21.8%), resulting in a general total methodological quality score of 72.5%. Overall younger adult age, male gender, ovulatory phase, positive expectations, attention to the conditioning stimulus, and carrier of the 5\u2010<jats:styled-content style=\"fixed-case\">HTTLPR<\/jats:styled-content> long allele result in better <jats:styled-content style=\"fixed-case\">CPM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It is advised for future studies to take these factors into account. Further research regarding the influence of oral contraceptives, catastrophizing, information about conditioning stimulation, distraction, physical activity, and genetics on <jats:styled-content style=\"fixed-case\">CPM<\/jats:styled-content> magnitude is required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12305","type":"journal-article","created":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T09:49:16Z","timestamp":1432633756000},"page":"758-769","source":"Crossref","is-referenced-by-count":121,"title":["Inventory of Personal Factors Influencing Conditioned Pain Modulation in Healthy People: A Systematic Literature Review"],"prefix":"10.1111","volume":"16","author":[{"given":"Linda","family":"Hermans","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences and Physiotherapy Faculty of Medicine and Health Sciences Ghent University Ghent Belgium"},{"name":"Pain in Motion Research Group 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