{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:04Z","timestamp":1787015944673,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T00:00:00Z","timestamp":1431993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>\n                      Hyperbaric oxygen therapy (\n                      <jats:styled-content style=\"fixed-case\">HBOT<\/jats:styled-content>\n                      ) is a treatment providing 100% oxygen at a pressure greater than that at sea level.\n                      <jats:styled-content style=\"fixed-case\">HBOT<\/jats:styled-content>\n                      is becoming increasingly recognized as a potential treatment modality for a broad range of ailments, including chronic pain. In this narrative review, we discuss the current understanding of pathophysiology of nociceptive, inflammatory and neuropathic pain, and the body of animal studies addressing mechanisms by which\n                      <jats:styled-content style=\"fixed-case\">HBOT<\/jats:styled-content>\n                      may ameliorate these different types of pain. Finally, we review clinical studies suggesting that\n                      <jats:styled-content style=\"fixed-case\">HBOT<\/jats:styled-content>\n                      may be useful in treating chronic pain syndromes, including chronic headache, fibromyalgia, complex regional pain syndrome, and trigeminal neuralgia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Database and data treatment<\/jats:title>\n                    <jats:p>\n                      A comprehensive search through\n                      <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>\n                      , Scopus, and Web of Science for studies relating to\n                      <jats:styled-content style=\"fixed-case\">HBOT<\/jats:styled-content>\n                      and pain was performed using the\u00a0following keywords: hyperbaric oxygen therapy or hyperbaric oxygen treatment (\n                      <jats:styled-content style=\"fixed-case\">HBOT<\/jats:styled-content>\n                      ), nociceptive pain, inflammatory pain, neuropathic pain,\n                      <jats:styled-content style=\"fixed-case\">HBOT AND<\/jats:styled-content>\n                      pain,\n                      <jats:styled-content style=\"fixed-case\">HBOT AND<\/jats:styled-content>\n                      \u00a0headache,\n                      <jats:styled-content style=\"fixed-case\">HBOT AND<\/jats:styled-content>\n                      fibromyalgia,\n                      <jats:styled-content style=\"fixed-case\">HBOT AND<\/jats:styled-content>\n                      complex\u00a0regional pain syndrome, and\n                      <jats:styled-content style=\"fixed-case\">HBOT AND<\/jats:styled-content>\n                      trigeminal neuralgia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010five studies examining the role of\n                      <jats:styled-content style=\"fixed-case\">HBOT<\/jats:styled-content>\n                      in animal models of pain and human clinical trials were found and reviewed for this narrative review.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">HBOT<\/jats:styled-content>\n                      has been shown to reduce pain using animal models. Early clinical research indicates\n                      <jats:styled-content style=\"fixed-case\">HBOT<\/jats:styled-content>\n                      may also be useful in modulating human pain; however, further studies are required to determine whether\n                      <jats:styled-content style=\"fixed-case\">HBOT<\/jats:styled-content>\n                      is a safe and efficacious treatment modality for chronic pain conditions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/papr.12312","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T01:57:59Z","timestamp":1432000679000},"page":"620-628","source":"Crossref","is-referenced-by-count":38,"title":["Hyperbaric Oxygen Therapy: A New Treatment for Chronic Pain?"],"prefix":"10.1111","volume":"16","author":[{"given":"Ainsley M.","family":"Sutherland","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Pain Management Toronto General Hospital University Health Network Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hance A.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Pain Management Toronto General Hospital University Health Network Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Pain Management Toronto General Hospital University Health Network Toronto ON Canada"},{"name":"Department of Psychology York University Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Katznelson","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Pain Management Toronto General Hospital University Health Network Toronto ON Canada"},{"name":"Hyperbaric Medical Unit Department of Anesthesia and Pain Management Toronto General Hospital Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,19]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Textbook of Hyperbaric Medicine","author":"Jain KK","year":"1999"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181fbe2bf"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2007.06.008"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2008.08.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.10044"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3283305a49"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.09.050"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.12.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.08.050"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2013.00448.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01446-7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.04.088"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2007.06.005"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.36076\/ppj.2005\/8\/157","article-title":"Effects of hyperbaric oxygen on skin blood flow and tissue morphology following sciatic nerve constriction","volume":"8","author":"Mychaskiw G","year":"2005","journal-title":"Pain Phys."},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2009.11.010"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1213\/ANE.0b013e31821f9544","article-title":"Hyperbaric oxygenation therapy alleviates chronic constrictive injury\u2010induced neuropathic pain and reduces tumor necrosis factor\u2010alpha production","volume":"113","author":"Li F","year":"2011","journal-title":"Anest Analg."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2012.00113.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/147043"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03011815"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.10.079"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-013-0213-3"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00724.x"},{"key":"e_1_2_9_25_1","first-page":"106","article-title":"Hyperbaric oxygen and acute migraine pain: preliminary results of a randomised blinded trial","volume":"19","author":"Fife CEM JS","year":"1992","journal-title":"Undersea Biomed Res."},{"key":"e_1_2_9_26_1","first-page":"106","article-title":"A blinded, crossover controlled study of the use of hyperbaric oxygen in the treatment of migraine headache","volume":"19","author":"Hill RK","year":"1992","journal-title":"Undersea Biomed Res."},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1995.hed3504197.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1998.3802112.x"},{"key":"e_1_2_9_29_1","first-page":"CD005219","article-title":"Normobaric and hyperbaric oxygen therapy for migraine and cluster headache","volume":"3","author":"Bennett MH","year":"2008","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(93)90137-E"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1996.3604221.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1984.hed2406294.x"},{"key":"e_1_2_9_33_1","first-page":"117","article-title":"Hyperbaric oxygen in chronic cluster headaches: influence on serotonergic pathways","volume":"24","author":"Di Sabato F","year":"1997","journal-title":"Undersea Hyperb Med."},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/426130"},{"key":"e_1_2_9_35_1","first-page":"355","article-title":"Morphology and pathogenesis of soft\u2010tissue rheumatism","volume":"32","author":"Fassbender HG","year":"1973","journal-title":"Z Rheumaforsch."},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009748609102084"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000403200305"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330203"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000403200304"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpapr.12312","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.12312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:07:42Z","timestamp":1695503262000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.12312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,19]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/papr.12312"],"URL":"https:\/\/doi.org\/10.1111\/papr.12312","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,19]]}}}