{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T20:51:57Z","timestamp":1760820717118},"reference-count":71,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T00:00:00Z","timestamp":1437523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the therapeutic efficacy of combined methylcobalamin and lidocaine for acute ophthalmic herpetic neuralgia (<jats:styled-content style=\"fixed-case\">AOHN<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based on the onset, patients with <jats:styled-content style=\"fixed-case\">AOHN<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a098) were randomly allocated into groups A (\u2264\u00a03\u00a0days) and B (4 to 7\u00a0days) and then subdivided into control (A0, B0; received intramuscular methylcobalamin in addition to local lidocaine injection) and treatment (A1, B1; received local injection of the methylcobalamin and lidocaine combination for 14\u00a0days) groups. Treatment efficacy was assessed based on rash healing time, alteration of pain intensity, and interference with quality of life. Multilevel modeling and survival analysis were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The time (hours) to start and full opening of the affected eye and the time (hours) to start and full crusting were significantly reduced in both treatment groups (<jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>0.05 vs. controls). The mean pain scores in A1 (2.6\u00a0\u00b1\u00a00.7) and B1 (1.2\u00a0\u00b1\u00a00.8) decreased significantly compared with those in A0 (7.0\u00a0\u00b1\u00a01.7) and B0 (5.6\u00a0\u00b1\u00a01.9), and the difference between the two therapeutic strategies significantly increased over time. The median minimum intervention time was 6\u00a0days in B1 and 11\u00a0days in A1. The incidence of postherpetic neuralgia (<jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content>) was 2.04% at 3\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Methylcobalamin combined with lidocaine mediated detumescence and improved cutaneous healing of the affected area, as well as a significant and sustained analgesic effect on <jats:styled-content style=\"fixed-case\">AOHN<\/jats:styled-content>. The incidence of <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> was also significantly decreased. Local methylcobalamin intervention within 4 to 7\u00a0days of onset may be an effective therapeutic option for <jats:styled-content style=\"fixed-case\">AOHN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12328","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T12:05:29Z","timestamp":1437566729000},"page":"869-881","source":"Crossref","is-referenced-by-count":9,"title":["Local Administration of Methylcobalamin and Lidocaine for Acute Ophthalmic Herpetic Neuralgia: A Single\u2010Center Randomized Controlled Trial"],"prefix":"10.1111","volume":"16","author":[{"given":"Gang","family":"X\u01d4","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine Affiliated Tenth People's Hospital of Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Site","family":"Xu","sequence":"additional","affiliation":[{"name":"Mechatronic Engineering and Automation School Shanghai University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Affiliated Tenth People's Hospital of Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"X\u00fa","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Affiliated Tenth People's Hospital of Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Zhen","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Affiliated Tenth People's Hospital of Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Affiliated Tenth People's Hospital of Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.03929.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1403.2002._2006.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2006.00489.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.10.009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198209000-00003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2007.10.008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01231.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/421942"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051016"},{"key":"e_1_2_7_11_1","first-page":"1","article-title":"Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"57","author":"Harpaz R","year":"2008","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_7_12_1","first-page":"S2","article-title":"Herpes zoster overview: natural history\u00a0and incidence","volume":"109","author":"Weaver BA","year":"2009","journal-title":"J Am Osteopath Assoc"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350712"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp013211"},{"key":"e_1_2_7_15_1","first-page":"CD006866","article-title":"Antiviral treatment for preventing postherpetic neuralgia","volume":"2","author":"Chen N","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2013.07.012"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/510206"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2013.01.002"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2009.04.004"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2008.00031.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.12.017"},{"key":"e_1_2_7_22_1","first-page":"1077","article-title":"Old or new medicine? Vitamin B12 and peripheral nerve neuropathy","volume":"65","author":"Tanaka H","year":"2013","journal-title":"Brain Nerve."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/424651"},{"key":"e_1_2_7_24_1","first-page":"48","article-title":"Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials","volume":"14","author":"Sun Y","year":"2005","journal-title":"Acta Neurol Taiwan."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12001"},{"key":"e_1_2_7_26_1","first-page":"426","article-title":"Treatment of Alzheimer\u2010type dementia with intravenous mecobalamin","volume":"14","author":"Ikeda T","year":"1992","journal-title":"Clin Ther"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900027589"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.53.1951"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12966"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/609705"},{"key":"e_1_2_7_31_1","first-page":"3469","article-title":"Analysis on clinical features and treatment of herpes zoster patients hospitalized in real world]","volume":"39","author":"Yuan LL","year":"2014","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12081"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000002"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.08.033"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.02999.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.08.046"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2010.02.020"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713688709020090"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.09.012"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.12_Suppl_8.S52"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-5155(00)00204-5"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1993.74"},{"key":"e_1_2_7_43_1","first-page":"324","article-title":"Anti\u2010nociceptive and anti\u2010inflammatory effects of cyanocobalamin (vitamin B12) against acute and chronic pain and inflammation in mice","volume":"62","author":"Hosseinzadeh H","year":"2012","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_7_44_1","first-page":"113","article-title":"Effect of cyanocobalamin (vitamin B12) in the induction and expression of morphine tolerance and dependence in mice","volume":"64","author":"Ghazanfari S","year":"2014","journal-title":"Drug Res (Stuttg)."},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-4087-0.00060-7"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199107000-00001"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2012.11.017"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-2199-9_16"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1990.00530090082017"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198806303182604"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.17.6.953"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/09637480802406153"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2006.05.001"},{"key":"e_1_2_7_54_1","first-page":"B485","article-title":"Oral better than parenteral supplementation of vitamin B12","volume":"153","author":"Duyvendak M","year":"2009","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200800865"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2011.539200"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01038-X"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00427267"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01646861"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1159\/000092643"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.12.027"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)90290-9"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/0303-8467(92)90066-C"},{"key":"e_1_2_7_64_1","first-page":"183","article-title":"Clinical usefulness of intrathecal injection of methylcobalamin in patients with diabetic neuropathy","volume":"9","author":"Ide H","year":"1987","journal-title":"Clin Ther"},{"key":"e_1_2_7_65_1","first-page":"162","article-title":"Clinical inquiry: is high\u2010dose oral B12 a safe and effective alternative to a B12 injection?","volume":"61","author":"Lin J","year":"2012","journal-title":"J Fam Pract"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.2006.00783.x"},{"key":"e_1_2_7_67_1","first-page":"1723","article-title":"Evaluation and management of herpes zoster ophthalmicus","volume":"66","author":"Shaikh S","year":"2002","journal-title":"Am Fam Physician"},{"key":"e_1_2_7_68_1","first-page":"413","article-title":"Sustained\u2010release pregabalin with methylcobalamin in neuropathic pain: an Indian real\u2010life experience","volume":"6","author":"Dongre YU","year":"2013","journal-title":"Int J Gen Med"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2013.1110567011"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-004833"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-529"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1957.01550140037006"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpapr.12328","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.12328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:42:42Z","timestamp":1695490962000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.12328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,22]]},"references-count":71,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/papr.12328"],"URL":"https:\/\/doi.org\/10.1111\/papr.12328","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,22]]}}}