{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:08:46Z","timestamp":1772752126699,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T00:00:00Z","timestamp":1443225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010290","name":"Fundaci\u00f3n Gr\u00fcnenthal","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010290","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Pain control in critical limb ischemia (CLI<\/jats:styled-content>) varies considerably between individuals.<\/jats:p><\/jats:sec>Objective<\/jats:title>To evaluate pharmacogenetically the response to transdermal buprenorphine (BUP<\/jats:styled-content>\u2010TTS<\/jats:styled-content>) in patients with CLI<\/jats:styled-content> who are awaiting revascularization.<\/jats:p><\/jats:sec>Methods<\/jats:title>One hundred and seven patients with CLI<\/jats:styled-content> were treated with BUP<\/jats:styled-content>\u2010TTS<\/jats:styled-content>. The following were analyzed: (1) pain perception (visual analog scale (VAS<\/jats:styled-content>) before and 4 days after treatment) and (2) genetics: glucuronosyltransferase (UGT<\/jats:styled-content>2B7), cytochrome (CYP<\/jats:styled-content>3A4), and \u03bc\u2010opioid receptor (OPRM<\/jats:styled-content>1) gene polymorphisms.<\/jats:p><\/jats:sec>Results<\/jats:title>Ninety\u2010three patients completed the study. The VAS<\/jats:styled-content> score by the fourth day of analgesia dropped from 6.82 to 3.38 (P<\/jats:italic> < 0.05). The analgesic response to BUP<\/jats:styled-content>\u2010TTS<\/jats:styled-content> was greater in men than in women (P<\/jats:italic> = 0.019). Patients who were AA<\/jats:styled-content> homozygotes for the CYP<\/jats:styled-content>3A4 gene showed the best response to analgesic treatment (P<\/jats:italic> = 0.003). The combination of the CYP<\/jats:styled-content>3A4 gene with UGT<\/jats:styled-content>2B7 or OPRM<\/jats:styled-content>1 was favorable to the effect of the CYP<\/jats:styled-content>3A4 gene (P<\/jats:italic> = 0.045 and P<\/jats:italic> = 0.026, respectively). The combination of UGT<\/jats:styled-content>2B7 with OPRM<\/jats:styled-content>1 was ineffective (P<\/jats:italic> = 0.648). The 3 polymorphisms together had no effect on response to treatment (P<\/jats:italic> = 0.461).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>BUP<\/jats:styled-content>\u2010TTS<\/jats:styled-content> is efficacious in the control of pain in patients with CLI<\/jats:styled-content>. The homozygous AA<\/jats:styled-content> carriers of the CYP<\/jats:styled-content>3A4 gene respond better to treatment with BUP<\/jats:styled-content>\u2010TTS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12343","type":"journal-article","created":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T08:10:17Z","timestamp":1443255017000},"page":"842-849","source":"Crossref","is-referenced-by-count":19,"title":["Influence of UGT<\/scp>2B7, CYP<\/scp>3A4, and OPRM<\/scp>1 Gene Polymorphisms on Transdermal Buprenorphine Pain Control in Patients with Critical Lower Limb Ischemia Awaiting Revascularization"],"prefix":"10.1111","volume":"16","author":[{"given":"Francisco","family":"Blanco","sequence":"first","affiliation":[{"name":"General Surgery Department Hospital Universitario de Salamanca\u2010IBSAL Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemente","family":"Muriel","sequence":"additional","affiliation":[{"name":"Anesthesiology and Reanimation Department Hospital Universitario de Salamanca\u2010IBSAL Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Labrador","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario de Burgos Burgos Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose R.","family":"Gonzalez\u2010Porras","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario de Salamanca\u2010IBSAL Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rogelio","family":"Gonzalez\u2010Sarmiento","sequence":"additional","affiliation":[{"name":"Molecular Medicine Unit\u2010Medicine Department Facultad de Medicina\u2010IBSAL\u2010Universidad de Salamanca\u2010CSIC Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco S.","family":"Lozano","sequence":"additional","affiliation":[{"name":"Angiology and Vascular Surgery Department, Hospital Universitario de Salamanca\u2010IBSAL Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,26]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"Second European Consensus Document Chronic Critical Leg Ischemia","volume":"84","author":"European Working Group on Critical Leg Ischemia","year":"1991","journal-title":"Circulation"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Management of peripheral arterial disease (PAD)","volume":"31","author":"TransAtlantic Inter\u2010Society Consensus (TASC)","year":"2000","journal-title":"J Vasc Surg"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.11.008"},{"key":"e_1_2_7_5_1","unstructured":"LericheR.Cirug\u00eda del dolor. 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