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For example, <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> administration results in a faster onset of pain relief and results in more predictable pharmacokinetics than does administration by other routes. It also allows for convenient dosing before or during surgery, permitting the initiation of effective analgesia in the early phase of the postoperative period. In addition, when patients are able to tolerate oral intake, they can be switched from <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> to oral dosing based on maintaining the predictable analgesia established by the <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> route. <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> morphine is widely used for the control of postoperative pain, but there is a trend toward the use of oxycodone. Oxycodone (which may be mediated partly through kappa\u2010 as well as mu\u2010opioid receptors) offers several potential advantages. Published studies comparing <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> oxycodone to other <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> opioids for postsurgical pain report that oxycodone is a safe and effective analgesic. Some studies show that <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> oxycodone may be associated with greater pain control, fewer or less severe adverse events, and faster onset of action, although the results are not consistent across all studies. Oxycodone has been reported to be safe in the geriatric and other special populations when adequate clinical adjustments are made. Thus, the clinical reports and oxycodone's pharmacologic profile make intravenous oxycodone a potentially important \u201cnew\u201d old drug for postoperative pain control.<\/jats:p>","DOI":"10.1111\/papr.12345","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T12:49:28Z","timestamp":1442926168000},"page":"924-934","source":"Crossref","is-referenced-by-count":24,"title":["Perspectives on Intravenous Oxycodone for Control of Postoperative Pain"],"prefix":"10.1111","volume":"16","author":[{"suffix":"Jr.","given":"Joseph V.","family":"Pergolizzi","sequence":"first","affiliation":[{"name":"Department of Medicine Johns Hopkins University School of Medicine Baltimore Maryland U.S.A"},{"name":"Department of Pharmacology Temple University School of Medicine Philadelphia Pennsylvania U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Seow\u2010Choen","sequence":"additional","affiliation":[{"name":"Fortis Colorectal Hospital Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Wexner","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Digestive Disease Center Cleveland Clinic Florida Weston Florida U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianpietro","family":"Zampogna","sequence":"additional","affiliation":[{"name":"NEMA Research Inc. 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