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Recently, accumulating evidence indicated that emotion has a significant role in pain perception of somatoform pain disorder. To further understand the association between emotion and pain\u2010related brain activities, functional activities of patients with PSPD fulfilling ICD\u201010 criteria and healthy controls were assessed using functional magnetic resonance imaging technology, while participants viewed a series of positive, neutral, or negative pictures with or without pinprick pain stimulation. Results showed that patients with PSPD had altered brain activities in the parietal gyrus, temporal gyrus, posterior cingulate cortex, prefrontal cortex, and parahippocampus in response to pinprick pain stimuli during different emotions compared with the healthy control group. Moreover, patients with PSPD consistently showed hyperactivities in the prefrontal, the fusiform gyrus and the insula in response to negative stimuli under pinprick pain vs. non\u2010pain condition. The current findings provide some insights into the underlying relationship between emotion and pain\u2010related brain activity in patients with PSPD, which is of both theoretical and clinical importance.<\/jats:p>","DOI":"10.1111\/papr.12358","type":"journal-article","created":{"date-parts":[[2016,9,19]],"date-time":"2016-09-19T11:17:05Z","timestamp":1474283825000},"page":"969-979","source":"Crossref","is-referenced-by-count":14,"title":["Altered Neural Correlates of Emotion Associated Pain Processing in Persistent Somatoform Pain Disorder: An fMRI Study"],"prefix":"10.1111","volume":"16","author":[{"given":"Yanli","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Psychiatry Tongji Hospital of Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Yan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Brain Functional Genomics Ministry of Education Shanghai Key Laboratory of Brain 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