{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:23:28Z","timestamp":1770513808578,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T00:00:00Z","timestamp":1455840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To evaluate the safety and efficacy of gabapentin in comparison with carbamazepine in the treatment of trigeminal neuralgia, a meta\u2010analysis of randomized controlled trials was performed. Two reviewers independently selected studies, assessed study quality, and extracted data. Sixteen randomized controlled trials that included 1,331 patients were assessed. The meta\u2010analysis showed that the total effective rate of gabapentin therapy group was similar with carbamazepine therapy group (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1.600, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.185, 2.161, <jats:italic>P<\/jats:italic> = 0.002). While the effective rate of gabapentin therapy for 4 weeks was higher than that of carbamazepine therapy (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1.495, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.061, 2.107, <jats:italic>P<\/jats:italic> = 0.022, heterogeneity: <jats:italic>x<\/jats:italic><jats:sup>2<\/jats:sup> = 7.12, <jats:italic>P<\/jats:italic> = 0.625, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 0.0%), the life satisfaction improvement is also better in the gabapentin therapy group after a 4\u2010week treatment (<jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content> = 0.966, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.583, 1.348, <jats:italic>P<\/jats:italic> &lt; 0.001). Furthermore, our meta\u2010analysis suggested that the adverse reaction rate of gabapentin therapy group was significantly lower than that of carbamazepine therapy group (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 0.312, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.240, 0.407, <jats:italic>P<\/jats:italic> &lt; 0.001). In conclusion, present trials comparing gabapentin with carbamazepine are all poor in terms of methodological quality. Based on the available evidence, it is not possible to draw conclusions regarding the efficacy and side effects of gabapentin being superior to carbamazepine.<\/jats:p>","DOI":"10.1111\/papr.12406","type":"journal-article","created":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T14:12:26Z","timestamp":1455977546000},"page":"1083-1091","source":"Crossref","is-referenced-by-count":48,"title":["Efficacy and Safety of Gabapentin vs. Carbamazepine in the Treatment of Trigeminal Neuralgia: A Meta\u2010Analysis"],"prefix":"10.1111","volume":"16","author":[{"given":"Min","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huang\u2010yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Immunology and Pathogenic Biology The Basic Medical College of Nanchang University Nanchang Jiangxi 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