{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:06:27Z","timestamp":1791389187429,"version":"4.3.3"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T00:00:00Z","timestamp":1456185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pain is a prevailing feature of cervical dystonia (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>), the most common form of focal dystonia. This analysis examined pain relief after onabotulinumtoxinA treatment in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> subjects with moderate\/severe pain from the Cervical Dystonia Patient Registry for Observation of OnabotulinumtoxinA Efficacy (<jats:styled-content style=\"fixed-case\">CD PROBE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CD PROBE<\/jats:styled-content> was a prospective, multicenter, observational registry of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> subjects who were na\u00efve to botulinum toxin (Bo<jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>), new to physician, or had not received Bo<jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content> within \u2265 16 weeks if in a clinical trial. Subjects were eligible for 3 treatments, with variable session intervals. Descriptive and inferential statistics were utilized to evaluate the change in pain scores in the population with moderate\/severe neck pain at baseline (Pain Numeric Rating Scale [<jats:styled-content style=\"fixed-case\">PNRS<\/jats:styled-content>] score 4 to 10).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1046 enrolled, 733 (70.7%) had moderate\/severe neck pain at baseline. Postinjection pain questionnaire responses 4 to 6 weeks after each of the 3 treatments revealed that a majority of subjects (67.1%, 72.4%, and 76.4%) reported pain relief; mean time to pain relief was 7.1, 7.4, and 7.6 days. All pain scales showed significant improvements from baseline to final visit (all <jats:italic>P<\/jats:italic> &lt; 0.0001): <jats:styled-content style=\"fixed-case\">PNRS<\/jats:styled-content>, mean 6.6 to 3.8; <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> Impact Profile\u201058 Pain and Discomfort subscale, mean 78.7 to 56.5; and Toronto Western Spasmodic Torticollis Rating Scale Pain subscale, mean 12.6 to 8.5. Multivariable regression models showed that initial pain score significantly contributed to the final pain score for all scales.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Results from this real\u2010world clinical registry indicate that a majority of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> subjects with moderate\/severe neck pain experience significant relief following onabotulinumtoxinA treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12408","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T04:48:28Z","timestamp":1456375708000},"page":"1073-1082","source":"Crossref","is-referenced-by-count":23,"title":["Neck Pain and Cervical Dystonia: Treatment Outcomes from CD PROBE (Cervical Dystonia Patient Registry for Observation of OnabotulinumtoxinA Efficacy)"],"prefix":"10.1111","volume":"16","author":[{"given":"P. David","family":"Charles","sequence":"first","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aubrey","family":"Manack Adams","sequence":"additional","affiliation":[{"name":"Allergan, Inc. Irvine California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Davis","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Bradley","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Schwartz","sequence":"additional","affiliation":[{"name":"MedNet Solutions, Inc. Minnetonka Minnesota U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell F.","family":"Brin","sequence":"additional","affiliation":[{"name":"Allergan, Inc. Irvine California U.S.A."},{"name":"University of California Irvine California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul T.","family":"Patel","sequence":"additional","affiliation":[{"name":"Kansas City Bone and Joint Clinic Overland Park Kansas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25475"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70232-0"},{"key":"e_1_2_8_4_1","first-page":"1","article-title":"Descriptive epidemiology of cervical dystonia","volume":"3","author":"Defazio G","year":"2013","journal-title":"Tremor Other Hyperkinet Mov (N Y)"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870060206"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.7.1088"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181fab0e4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23139"},{"issue":"12","key":"e_1_2_8_9_1","first-page":"S15","article-title":"Use of botulinum toxin type A in the treatment of cervical dystonia","volume":"55","author":"Comella CL","year":"2000","journal-title":"Neurology"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-11-140"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7343-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e31826538c7"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.8.1213"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-013-1048-3"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2011.01245.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20403"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.09.012"},{"issue":"1","key":"e_1_2_8_18_1","first-page":"445","article-title":"The Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS): assessment of validity and inter\u2010rate reliability [abstract]","volume":"40","author":"Consky E","year":"1990","journal-title":"Neurology"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000142962.11881.26"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25579"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120414"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000249310.25427.f2"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.09.033"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.01.028"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/75.4.800"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.05.041"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000183055.81056.5c"},{"key":"e_1_2_8_28_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/WNF.0b013e3181c46f48","article-title":"A prospective, randomized, double\u2010blind study comparing the efficacy and safety of type a botulinum toxins botox and prosigne in the treatment of cervical dystonia","volume":"33","author":"Quagliato EM","year":"2010","journal-title":"Clin Neuropharmacol"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21724"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-70942009000300013"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.06.013"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins6020592"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins2122890"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414527648"},{"key":"e_1_2_8_35_1","first-page":"S23","article-title":"Botulinum toxin type\u2010A and pain responsiveness in cervical dystonia: a dose response study","volume":"20","author":"Relja M","year":"2005","journal-title":"Mov Disord"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870020402"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2014.11.210"},{"key":"e_1_2_8_38_1","first-page":"155","volume-title":"Epidemiology \u2013 Current Perspectives on Research and Practice","author":"Manack A","year":"2012"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.12.030"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpapr.12408","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.12408","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/papr.12408","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.12408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T13:59:16Z","timestamp":1695736756000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.12408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,23]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/papr.12408"],"URL":"https:\/\/doi.org\/10.1111\/papr.12408","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,23]]}}}