{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:19:53Z","timestamp":1792714793979,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T00:00:00Z","timestamp":1456963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Two of the most common Quantitative Sensory Techniques (<jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content>) employed to detect allodynia include mechanical brush allodynia and Semmes\u2013Weinstein monofilaments. However, their relative sensitivity at detecting allodynia is poorly understood. The purpose of this study was to compare the sensitivity of brush allodynia against Semmes\u2013Weinstein monofilament technique for detecting allodynia within regions of secondary hyperalgesia in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty subjects (10 males, 10 females; 21.1 \u00b1 0.9 years) were recruited and randomly allocated to allodynia or monofilament groups. Topical capsaicin (Zostrix 0.075%) was applied to a target region defined by C4\u2013C7 dermatomes. Allodynia testing was performed at 0\u2010 (baseline) and 10 minutes postcapsaicin. The Semmes\u2013Weinstein group assessed changes in skin sensitivity 8 cm inferior to target region and 2 cm lateral to the spinous process, while brush allodynia was employed to detect the point inferior to the target region where subjects reported changes in skin sensitivity. The distance (cm) from this point to the inferior border of the target region was termed the Allodynia Score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Statistically significant increases in the Allodynia Score were observed at 10 minutes postcapsaicin compared to baseline (<jats:italic>P<\/jats:italic> &lt; 0.001). No differences in monofilament scores were observed between 10 minutes postcapsaicin and baseline (<jats:italic>P<\/jats:italic> = 0.125). Brush allodynia also demonstrated superior sensitivity, detecting allodynia in 100% of cases compared to 60% in the Semmes\u2013Weinstein group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Brush allodynia is more sensitive than Semmes\u2013Weinstein monofilaments for detecting mechanical allodynia in regions of secondary hyperalgesia. Brush allodynia may be preferred over Semmes\u2013Weinstein monofilaments for clinical applications requiring reliable detection of allodynia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12418","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T07:54:22Z","timestamp":1456991662000},"page":"16-24","source":"Crossref","is-referenced-by-count":6,"title":["A Comparison of the Sensitivity of Brush Allodynia and Semmes\u2013Weinstein Monofilament Testing in the Detection of Allodynia Within Regions of Secondary Hyperalgesia in Humans"],"prefix":"10.1111","volume":"17","author":[{"given":"Emmalee C.","family":"Maracle","sequence":"first","affiliation":[{"name":"Human Health and Nutritional Sciences University of Guelph Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie Y.","family":"Hung","sequence":"additional","affiliation":[{"name":"Human Health and Nutritional Sciences University of Guelph Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina I.","family":"Fell","sequence":"additional","affiliation":[{"name":"Human Health and Nutritional Sciences University of Guelph Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Osmond","sequence":"additional","affiliation":[{"name":"Human Health and Nutritional Sciences University of Guelph Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H. 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