{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:54:50Z","timestamp":1789750490849,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T00:00:00Z","timestamp":1476403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Shenzhen Key Laboratory for Pain Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>We demonstrated a combination of pulsed radiofrequency (PRF<\/jats:styled-content>) and cervical nerve root block (CNRB<\/jats:styled-content>) via a posterior approach was superior to a transforaminal epidural steroid injection through the anterolateral approach for cervical radicular pain in a previous study. This randomized trial was conducted to determine the comparative efficacy between CNRB<\/jats:styled-content>, PRF<\/jats:styled-content>, and CNRB<\/jats:styled-content> + PRF<\/jats:styled-content> for cervical radicular pain.<\/jats:p><\/jats:sec>Methods<\/jats:title>A prospective and randomized design was used in this study. Sixty\u2010two patients were randomized into three parallel groups: CNRB<\/jats:styled-content>, PRF<\/jats:styled-content>, or CNRB<\/jats:styled-content> + PRF<\/jats:styled-content>. Numeric Rating Scale (NRS<\/jats:styled-content>) was used to measure pain intensity, and global perceived effect (GPE<\/jats:styled-content>) was scored by the patient on a 7\u2010point scale, ranging from much worse (\u22123), no change (0), to total improvement (+3). The outcomes were evaluated at 1 week, 1 month, 3 months, and 6 months. Side effects and complications were noted.<\/jats:p><\/jats:sec>Results<\/jats:title>The NRS<\/jats:styled-content> was significantly reduced in all three groups 1 week after the treatments (P<\/jats:italic> < 0.001), and the rates of positive GPE<\/jats:styled-content> (+2 or +3) were not significantly different between the three groups. At 1, 3, and 6 months of follow\u2010ups, the combined therapy achieved significantly lower NRS<\/jats:styled-content> and higher GPE<\/jats:styled-content> compared to CNRB<\/jats:styled-content> or PRF<\/jats:styled-content> alone group (P<\/jats:italic> < 0.001). There were no significant differences between the CNRB<\/jats:styled-content> and PRF<\/jats:styled-content> groups (P<\/jats:italic> > 0.05). No serious complications were observed in any of the patients.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Combining CNRB<\/jats:styled-content> and PRF<\/jats:styled-content> appeared to be a safe and efficacious technique for cervical radicular pain. The combination therapy yielded better outcomes than either CNRB<\/jats:styled-content> or PRF<\/jats:styled-content> alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12493","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T06:30:14Z","timestamp":1476426614000},"page":"589-595","source":"Crossref","is-referenced-by-count":20,"title":["A Randomized Comparative Study of Pulsed Radiofrequency Treatment With or Without Selective Nerve Root Block for Chronic Cervical Radicular Pain"],"prefix":"10.1111","volume":"17","author":[{"given":"Fei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology & Pain Medicine Guangdong Medical College HuiZhou First Hospital Jiangbei, Huizhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pain Management Guangdong Medical College Shenzhen Nanshan Hospital Nanshan, Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pain Management Guangdong Medical College Shenzhen Nanshan Hospital Nanshan, Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pain Management Guangdong Medical College Shenzhen Nanshan Hospital Nanshan, Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglin","family":"Xong","sequence":"additional","affiliation":[{"name":"Department of Pain Management Guangdong Medical College Shenzhen Nanshan Hospital Nanshan, Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Disen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pain Management Guangdong Medical College Shenzhen Nanshan Hospital Nanshan, Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LiPing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pain Management Anesthesiology Institute Cleveland Clinic Cleveland Ohio U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigdha","family":"Ancha","sequence":"additional","affiliation":[{"name":"Department of Pain Management Anesthesiology Institute Cleveland Clinic Cleveland Ohio U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pain Management Anesthesiology Institute Cleveland Clinic Cleveland Ohio 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