{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:22:56Z","timestamp":1781245376232,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T00:00:00Z","timestamp":1476403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Cotera Inc"},{"name":"Zimmer Biomet Inc"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Cervical neck pain is often caused by cervical disk pathology and may cause severe symptoms and disability. Surgeons and patients are increasingly aware of postsurgery\u2010related complications. This stimulated the clinical usage of minimally invasive treatments such as percutaneous nucleoplasty (PCN<\/jats:styled-content>) and pulsed radio frequency (PRF<\/jats:styled-content>). However, scientific evidence on both treatments is limited.<\/jats:p><\/jats:sec>Objective<\/jats:title>Our objective was to evaluate the efficacy of PCN<\/jats:styled-content> compared to PRF<\/jats:styled-content> in patients with contained cervical disk herniation.<\/jats:p><\/jats:sec>Methods<\/jats:title>A prospective randomized clinical trial was conducted including 34 patients with radicular pain due to a single contained cervical disk herniation who were treated with either PCN<\/jats:styled-content> or PRF<\/jats:styled-content>. Demographic data were collected, and the Medical Outcomes Study 12\u2010Item Short Form (SF<\/jats:styled-content>\u201012) Health Survey, visual analog scale (VAS<\/jats:styled-content>), and the Neck Disability Index (NDI<\/jats:styled-content>) were completed 1, 2, and 3 months after treatment. Treatment satisfaction and complications were recorded.<\/jats:p><\/jats:sec>Results<\/jats:title>In the PCN<\/jats:styled-content> group (n<\/jats:italic> = 17, mean age 52.4 years, 10 female\/7 male), patients were treated at C5 to C6 (8 cases) or C6 to C7 (9 cases). In the PRF<\/jats:styled-content> group (n<\/jats:italic> = 17, mean age 49.5 years, 8 female\/9 male), patients were treated at C3 to C4 (1 case), C5 to C6 (10 cases), or C6 to C7 (6 cases). At 3 months, mean pain VAS<\/jats:styled-content> improved significantly from baseline in the PCN<\/jats:styled-content> group (mean improvement: 43.4 points) and in the PRF<\/jats:styled-content> group (34.0 points). However, improvement in 1 group was not superior compared to the other group (P<\/jats:italic> = 0.48). No serious complications were reported.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Within 3 months, both PCN<\/jats:styled-content> and PRF<\/jats:styled-content> show significant pain improvement in patients with contained cervical disk herniation, but none is superior to the other. Both treatment options appear to be effective and safe in regular clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12517","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T21:18:07Z","timestamp":1473455887000},"page":"729-737","source":"Crossref","is-referenced-by-count":20,"title":["Percutaneous Cervical Nucleoplasty vs. Pulsed Radio Frequency of the Dorsal Root Ganglion in Patients with Contained Cervical Disk Herniation; A Prospective, Randomized Controlled Trial"],"prefix":"10.1111","volume":"17","author":[{"given":"Willy","family":"Halim","sequence":"first","affiliation":[{"name":"Anna Hospital Geldrop The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"van der Weegen","sequence":"additional","affiliation":[{"name":"Anna Hospital Geldrop The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toine","family":"Lim","sequence":"additional","affiliation":[{"name":"Anna Hospital Geldrop The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorgen Antonin","family":"Wullems","sequence":"additional","affiliation":[{"name":"Anna Hospital Geldrop The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris Christiaan","family":"Vissers","sequence":"additional","affiliation":[{"name":"Radboudumc Medical Center Nijmegen the 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