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Risk factors for\n                      <jats:styled-content style=\"fixed-case\">CPSP<\/jats:styled-content>\n                      after autologous breast reconstruction have not been clearly established. Previously, we demonstrated that transversus abdominis plane (\n                      <jats:styled-content style=\"fixed-case\">TAP<\/jats:styled-content>\n                      ) catheters delivering intermittent local anesthetic reduced postoperative morphine consumption. This prospective follow\u2010up study aimed to (1) compare the incidence of\n                      <jats:styled-content style=\"fixed-case\">CPSP<\/jats:styled-content>\n                      after autologous breast reconstruction between patients who received postoperative intermittent\n                      <jats:styled-content style=\"fixed-case\">TAP<\/jats:styled-content>\n                      catheters with bupivacaine or saline boluses and (2) assess the factors that contribute to the development and maintenance of\n                      <jats:styled-content style=\"fixed-case\">CPSP<\/jats:styled-content>\n                      in this study cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010three patients who underwent deep inferior epigastric artery perforator or muscle\u2010sparing transverse rectus abdominis breast reconstruction were randomized to receive\n                      <jats:styled-content style=\"fixed-case\">TAP<\/jats:styled-content>\n                      catheters with bupivacaine or saline postoperatively. Subsequently, patients were followed for a year to assess persistent pain, pain severity, quality of life scores, and functional disability at 6 and 12\u00a0months after surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010four percent and 23% of patients reported\n                      <jats:styled-content style=\"fixed-case\">CPSP<\/jats:styled-content>\n                      at 6 and 12\u00a0months, respectively. There were no significant differences between groups (bupivacaine vs. placebo) on pain\u2010related variables, including incidence of\n                      <jats:styled-content style=\"fixed-case\">CPSP<\/jats:styled-content>\n                      . Patients who reported greater variability in pain scores at rest over the first 48\u00a0hours postoperatively were more likely to have\n                      <jats:styled-content style=\"fixed-case\">CPSP<\/jats:styled-content>\n                      6\u00a0months, but not 12\u00a0months, later.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Acute postoperative pain variability may contribute to the development of\n                      <jats:styled-content style=\"fixed-case\">CPSP<\/jats:styled-content>\n                      up to 6\u00a0months after autologous breast reconstruction surgery. Neither postoperative use of bupivacaine vs. saline in the\n                      <jats:styled-content style=\"fixed-case\">TAP<\/jats:styled-content>\n                      catheters nor acute pain severity influenced the 6\u2010 or 12\u2010month incidence of\n                      <jats:styled-content style=\"fixed-case\">CPSP<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/papr.12550","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T08:22:46Z","timestamp":1482222166000},"page":"999-1007","source":"Crossref","is-referenced-by-count":12,"title":["Chronic Postsurgical Pain Outcomes in Breast Reconstruction Patients Receiving Perioperative Transversus Abdominis Plane Catheters at the Donor Site: A Prospective Cohort Follow\u2010up Study"],"prefix":"10.1111","volume":"17","author":[{"given":"Justin","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Pain Management Toronto General Hospital Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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Anaesthesia University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne C.","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery Toronto General Hospital University Health Network, University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Kahn","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Pain Management Toronto General Hospital Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Pain Management Toronto General Hospital Toronto Ontario Canada"},{"name":"Department of Anaesthesia University of Toronto Toronto Ontario Canada"},{"name":"Department of Psychology York University Toronto Ontario 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