{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:03:33Z","timestamp":1788822213275,"version":"build-2803163510"},"reference-count":95,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T00:00:00Z","timestamp":1499731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n \n Several authors have evaluated different pain measurements, including quantitative sensory testing (\n QST<\/jats:styled-content>\n ), temporal summation (\n TS<\/jats:styled-content>\n ), and conditioned pain modulation (\n CPM<\/jats:styled-content>\n ) in order to determine the presence of central sensitization (\n CS<\/jats:styled-content>\n ) and its influence on patients with temporomandibular disorders (\n TMD<\/jats:styled-content>\n ). Since there are no convincing studies about this topic, the purpose of this study was to conduct a review of the studies involving\n CS<\/jats:styled-content>\n \u2010related measures in\n TMD<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A meta\u2010analysis of case\u2010control and cohort\/cross sectional studies was conducted. Standardized mean differences (\n SMD<\/jats:styled-content>\n ) and 95% confidence intervals (\n CI<\/jats:styled-content>\n s) were calculated for relevant\n QST<\/jats:styled-content>\n outcomes and pooled in a meta\u2010analysis using the random effects model. Twenty\u2010two studies (eleven case\u2010control and eleven cross sectional studies) met the inclusion criteria; eight were included in the meta\u2010analysis (five cross\u2010sectional and three case\u2010control). Patients with\n TMD<\/jats:styled-content>\n had decreased pressure pain thresholds in both trigeminal (five studies;\n n<\/jats:italic>\n = 1,985;\n SMD<\/jats:styled-content>\n = \u22121.55, 95%\n CI<\/jats:styled-content>\n \u22122.23 to \u22120.77;\n P<\/jats:italic>\n < 0.01) and remote areas (five studies;\n n<\/jats:italic>\n = 1,985;\n SMD<\/jats:styled-content>\n = \u22121.92, 95%\n CI<\/jats:styled-content>\n \u22122.95 to \u22120.89;\n P<\/jats:italic>\n < 0.01). When analyzing for thermal hyperalgesia (hot and cold pain thresholds), differences were not found in trigeminal areas or remote areas in patients with\n TMD<\/jats:styled-content>\n . The\n TS<\/jats:styled-content>\n qualitative analysis showed strong evidence of spinal hyperexcitability for mechanically evoked pain.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n These meta\u2010analyses support the existence of differences in widespread pressure pain sensitivity in patients with\n TMD<\/jats:styled-content>\n when compared with asymptomatic subjects. Spinal and central hyperexcitability can be found in\n TMD<\/jats:styled-content>\n patients as shown by an increase in mechanical\n TS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/papr.12604","type":"journal-article","created":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T09:36:37Z","timestamp":1496050597000},"page":"388-409","source":"Crossref","is-referenced-by-count":111,"title":["Evidence for Central Sensitization in Patients with Temporomandibular Disorders: A Systematic Review and Meta\u2010analysis of Observational Studies"],"prefix":"10.1111","volume":"18","author":[{"given":"Roy","family":"La Touche","sequence":"first","affiliation":[{"name":"Department of Physiotherapy Centro Superior de Estudios Universitarios La Salle Universidad Aut\u00f3noma de Madrid Madrid Spain"},{"name":"Motion in Brains Research Group Centro Superior de Estudios Universitarios La Salle Universidad Aut\u00f3noma de Madrid Madrid Spain"},{"name":"Institute of Neuroscience and Craniofacial Pain (INDCRAN) Madrid Spain"},{"name":"Hospital La Paz Institute for Health Research IdiPAZ Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Paris\u2010Alemany","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Centro Superior de Estudios Universitarios La Salle Universidad Aut\u00f3noma de Madrid Madrid Spain"},{"name":"Motion in Brains Research Group Centro Superior de Estudios Universitarios La Salle Universidad Aut\u00f3noma de Madrid Madrid Spain"},{"name":"Institute of Neuroscience and Craniofacial Pain (INDCRAN) Madrid Spain"},{"name":"Hospital La Paz Institute for Health Research IdiPAZ Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Hidalgo\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Centro Superior de Estudios Universitarios La Salle Universidad Aut\u00f3noma de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibai","family":"L\u00f3pez\u2010de\u2010Uralde\u2010Villanueva","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Centro Superior de Estudios Universitarios La Salle Universidad Aut\u00f3noma de Madrid Madrid Spain"},{"name":"Motion in Brains Research Group Centro Superior de Estudios Universitarios La Salle Universidad Aut\u00f3noma de Madrid Madrid Spain"},{"name":"Institute of Neuroscience and Craniofacial Pain (INDCRAN) Madrid Spain"},{"name":"Hospital La Paz Institute for Health Research IdiPAZ Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Angulo\u2010Diaz\u2010Parre\u00f1o","sequence":"additional","affiliation":[{"name":"Motion in Brains Research Group Centro Superior de Estudios Universitarios La Salle Universidad Aut\u00f3noma de Madrid Madrid Spain"},{"name":"Faculty of Medicine San Pablo CEU University Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Mu\u00f1oz\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Centro Superior de Estudios Universitarios La Salle Universidad Aut\u00f3noma de Madrid Madrid Spain"},{"name":"Motion in Brains Research Group Centro Superior de Estudios Universitarios La Salle Universidad Aut\u00f3noma de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"Article 512792","DOI":"10.1155\/2015\/512792","article-title":"Jaw dysfunction is associated with neck disability and muscle tenderness in subjects with and without chronic temporomandibular disorders","volume":"2015","author":"Silveira A","year":"2015","journal-title":"Biomed Res Int"},{"key":"e_1_2_9_3_1","first-page":"102","article-title":"A review of temporomandibular joint disease (TMJD). 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