{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:43:45Z","timestamp":1773351825161,"version":"3.50.1"},"reference-count":134,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Opioids provide effective relief from moderate\u2010to\u2010severe pain and should be prescribed as part of a multifaceted approach to pain management when other treatments have failed. Fixed\u2010dose oxycodone\/naloxone prolonged\u2010release tablets (<jats:styled-content style=\"fixed-case\">OXN PR<\/jats:styled-content>) were designed to address the opioid class effect of opioid\u2010induced constipation (<jats:styled-content style=\"fixed-case\">OIC<\/jats:styled-content>) by combining the analgesic efficacy of oxycodone with the opioid receptor antagonist, naloxone, which has negligible systemic availability when administered orally. This formulation has abuse\u2010deterrent properties, since systemic exposure to naloxone by parenteral administration would antagonize the euphoric effects of oxycodone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was conducted to assess the evidence base for <jats:styled-content style=\"fixed-case\">OXN PR<\/jats:styled-content> to treat moderate\u2010to\u2010severe pain and its impact on bowel function, based on published clinical trials and observational studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Extensive data demonstrate that <jats:styled-content style=\"fixed-case\">OXN PR<\/jats:styled-content> provides effective analgesia and clinically relevant improvements in bowel function in patients with <jats:styled-content style=\"fixed-case\">OIC<\/jats:styled-content> and moderate\u2010to\u2010severe cancer\u2010related pain and noncancer pain types such as low back pain, neuropathic pain, and musculoskeletal pain. <jats:styled-content style=\"fixed-case\">OXN PR<\/jats:styled-content> has also been found to improve bowel function in patients with <jats:styled-content style=\"fixed-case\">OIC<\/jats:styled-content> refractory to multiple types of laxatives, and improve Parkinson's disease\u2013related pain. No unanticipated safety concerns have been reported in elderly patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Evidence from clinical trials and observational studies confirms that for selected patients <jats:styled-content style=\"fixed-case\">OXN PR<\/jats:styled-content> significantly improves moderate\u2010to\u2010severe chronic pain and provides relief from <jats:styled-content style=\"fixed-case\">OIC<\/jats:styled-content>. Treatment should be tailored to individual patients to establish the lowest effective dose. An absence of analgesic ceiling effect was seen across the clinically relevant dose range investigated (\u2264 160\/80 mg\/day).<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12646","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T11:23:08Z","timestamp":1506338588000},"page":"647-665","source":"Crossref","is-referenced-by-count":34,"title":["Oral Prolonged\u2010Release Oxycodone\/Naloxone for Managing Pain and Opioid\u2010Induced Constipation: A Review of the Evidence"],"prefix":"10.1111","volume":"18","author":[{"given":"Bart J.","family":"Morlion","sequence":"first","affiliation":[{"name":"Leuven Centre for Algology and Pain Management Anaesthesiology and Algology Department of Cardiovascular Sciences University Hospitals Leuven University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan A.","family":"Mueller\u2010Lissner","sequence":"additional","affiliation":[{"name":"Independent Researcher Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Vellucci","sequence":"additional","affiliation":[{"name":"Palliative Care and Pain Therapy Unit University Hospital Careggi Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Leppert","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine Poznan University of Medical Sciences Poznan Poland"},{"name":"Department of Quality of Life Research Medical University of Gdansk Gdansk Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beno\u00eet C.","family":"Coffin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Louis Mourier Hospital Assistance Publique \u2010 H\u00f4pitaux de Paris Colombes France"},{"name":"University Denis Diderot\u2010Paris VII Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara L.","family":"Dickerson","sequence":"additional","affiliation":[{"name":"Mundipharma International Ltd Cambridge Science Park Cambridge U.K"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Marymount University Hospital and Hospice Cork Ireland"},{"name":"Cork University Hospital and College of Medicine and Health University College Cork Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2010.545813"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.06.009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2015.12.340"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp14X680737"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2008.10.008"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70040-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.970"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.5055\/jom.2009.0015"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2008.00495.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12937"},{"key":"e_1_2_6_12_1","first-page":"1837","article-title":"Opioid\u2010induced constipation and bowel dysfunction: clinical guideline","volume":"18","author":"Mueller\u2010Lissner S","year":"2017","journal-title":"Pain Med"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12417"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjpain.2015.12.005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12718"},{"key":"e_1_2_6_16_1","first-page":"1932","article-title":"Laxatives do not improve symptoms of opioid\u2010induced constipation: results of a patient survey","volume":"18","author":"Emmanuel A","year":"2017","journal-title":"Pain Med"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2016.22.3.246"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2016.1129275"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/11634970-000000000-00000"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2009.03.012"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2012.657301"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323001103900106"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2010.535270"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.03.008"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.431"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002820-198906000-00012"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696990903430481"},{"key":"e_1_2_6_28_1","unstructured":"NappPharmaceuticals.Targinact summary of product characteristics.http:\/\/www.medicines.org.uk\/emc\/medicine\/22908(accessed January 13 2017)."},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.5414\/CP201646"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2008.01820.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2008.06.012"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2008.11.008"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2003.09.011"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000200"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2012.02764.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/497217"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000148618.17736.3C"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100262"},{"key":"e_1_2_6_39_1","first-page":"857","article-title":"Ultra\u2010low\u2010dose naloxone or naltrexone to improve opioid analgesia: the history, the mystery and a novel approach","volume":"2","author":"Burns LH","year":"2010","journal-title":"Clin Med Insights Ther"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/278740a0"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2435-5"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269216311418869"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1054"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1050"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-3709-5"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S92998"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S108144"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2011.02634.x"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909113510058"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204428"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.130"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2008.543"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2011.03.019"},{"key":"e_1_2_6_54_1","unstructured":"National Institute for Health and Care Excellence.Low back pain and sciatica in over 16s: assessment and management (NICE guideline NG59).https:\/\/www.nice.org.uk\/guidance\/ng59\/chapter\/Recommendations#non-invasive-treatments-for-low-back-pain-and-sciatica(accessed March 03 2017)."},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-7-200710020-00006"},{"key":"e_1_2_6_56_1","volume-title":"Evidence\u2010Informed Primary Care Managenet of Low Back Pain: Clinical Practice Guideline","author":"Toward Optimized Practice (TOP) Low Back Pain Working Group"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-006-1072-1"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2010.03.032"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.11.011"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2008.06.014"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2010.02360.x"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/164609"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S94685"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2015.1047747"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S88076"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S112418"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12468"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12361"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12308"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.06.017"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.2217\/pmt.15.53"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70251-0"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656560902796798"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990802584454"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2012.648615"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2013.866545"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-012-0074-0"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu350.20"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.03.018"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21596"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6904-10-12"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12463"},{"key":"e_1_2_6_83_1","first-page":"38","article-title":"Combined administration of oxycodone\/naloxone in chronic osteo\u2010articular diseases pain therapy","volume":"9","author":"Rosa P","year":"2014","journal-title":"Transl Med UniSa"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2015.1001737"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjpain.2014.01.004"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007991003787318"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22142"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70068-7"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00243-4"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7823-3"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.12.008"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12051"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1396682"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1177\/030006051204000516"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2016.04.002"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-013-1770-x"},{"key":"e_1_2_6_97_1","first-page":"19","article-title":"Single\u2010shot epidural\u2010spinal anesthesia followed by oral oxycodone\/naloxone and ketoprofen combination in patients undergoing total hip replacement: analgesic efficacy and tolerability","volume":"81","author":"Scardino M","year":"2015","journal-title":"Minerva Anestesiol"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10322"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-016-0456-9"},{"key":"e_1_2_6_100_1","unstructured":"GoebellPJ BaranowskiA van OphovenA et al.Bladder function and quality of life benefits of prolonged\u2010release oxycodone\/naloxone (OXN PR) in patients with bladder pain syndrome (BPS). 9th Congress of the European Pain Federation.Vienna Austria. EFIC5\u20100713."},{"key":"e_1_2_6_101_1","unstructured":"GoebellPJ BaranowskiA vanOphovenA et al.Safety and analgesic efficacy of prolonged\u2010release oxycodone\/naloxone (OXN PR) in patients suffering from severe pain due to bladder pain syndrome (BPS). 9th Congress of the European Pain Federation.Vienna Austria. EFIC\u20100716."},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2012.01349.x"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.05.002"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2009.02376.x"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2008.00204.x"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-016-0381-2"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2013.851082"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S106025"},{"key":"e_1_2_6_109_1","first-page":"1","article-title":"Efficacy and tolerability of low\u2010dose oral prolonged\u2010release oxycodone\/naloxone for chronic nononcological pain in older patients","volume":"10","author":"Guerriero F","year":"2015","journal-title":"Clin Interv Aging"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S98511"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2014.971355"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-016-0051-4"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2015.02.010"},{"key":"e_1_2_6_114_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.36076\/ppj.2014\/17\/415","article-title":"Effect of a fixed\u2010dose opioid agonist\/antagonist on constipation in patients on long\u2010term opioids for non\u2010malignant pain unable to tolerate laxatives","volume":"17","author":"Mehta V","year":"2014","journal-title":"Pain Physician"},{"key":"e_1_2_6_115_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2012.665279"},{"key":"e_1_2_6_116_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2015.1116992"},{"key":"e_1_2_6_117_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2014.894501"},{"key":"e_1_2_6_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-016-0059-9"},{"key":"e_1_2_6_119_1","first-page":"160","article-title":"Increased burden of healthcare utilization and cost associated with opioid\u2010related constipation among patients with noncancer pain","volume":"9","author":"Fernandes AW","year":"2016","journal-title":"Am Health Drug Benefits"},{"key":"e_1_2_6_120_1","first-page":"93","article-title":"Economic burden of opioid\u2010induced constipation among long\u2010term opioid users with noncancer pain","volume":"8","author":"Wan Y","year":"2015","journal-title":"Am Health Drug Benefits"},{"key":"e_1_2_6_121_1","first-page":"CD003448","article-title":"Laxatives or methylnaltrexone for the management of constipation in palliative care patients","author":"Candy B","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_122_1","first-page":"CD003448","article-title":"Laxatives for the management of constipation in people receiving palliative care","author":"Candy B","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_123_1","first-page":"e21009","article-title":"Treatment of failed back surgery syndrome in a forty\u2010three\u2010year\u2010old man with high\u2010dose oxycodone\/naloxone","volume":"5","author":"Bujedo BM","year":"2015","journal-title":"Anesth Pain Med"},{"key":"e_1_2_6_124_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2008\/11\/S105"},{"key":"e_1_2_6_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2013.03.015"},{"key":"e_1_2_6_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.237"},{"key":"e_1_2_6_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.02.014"},{"key":"e_1_2_6_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2010.04.003"},{"key":"e_1_2_6_129_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00042"},{"key":"e_1_2_6_130_1","unstructured":"HarrisS PerrinoP ShramM et al.Abuse potential of oxycodone\/naloxone (OXN) tablets administered intranasally in nondependent recreational drug users with moderate opioid experience. PAINWeek.2013;abstract 40:70\u201371.http:\/\/www.painweek.org\/assets\/documents\/painweek-page\/650-painweek2013acceptedabstracts.pdf(accessed August 30 2017)"},{"key":"e_1_2_6_131_1","unstructured":"WangY PerrinoP BartlettC et al.Abuse potential of chewed or intact oxycodone\/naloxone (OXN) tablets in methadone\u2010stabilized opioid\u2010dependent subjects when administered orally. PAINWeek.2013;abstract 134:225\u2013226.http:\/\/www.painweek.org\/assets\/documents\/painweek-page\/650-painweek2013acceptedabstracts.pdf(accessed August 30 2017)"},{"key":"e_1_2_6_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-014-0192-3"},{"key":"e_1_2_6_133_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1406143"},{"key":"e_1_2_6_134_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1512932"},{"key":"e_1_2_6_135_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11469-015-9590-x"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpapr.12646","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.12646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:10:26Z","timestamp":1695492626000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.12646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,28]]},"references-count":134,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/papr.12646"],"URL":"https:\/\/doi.org\/10.1111\/papr.12646","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,28]]}}}