{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T04:29:14Z","timestamp":1695529754917},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T00:00:00Z","timestamp":1513296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We aimed to evaluate the incidence of (and risk factors for) postoperative pregabalin and\/or limaprost to treat persistent numbness and\/or pain of the lower extremities after lumbar spinal stenosis (<jats:styled-content style=\"fixed-case\">LSS<\/jats:styled-content>) surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of 329 patients (168 men, 161 women; average age 70\u00a0years) were retrospectively reviewed for data on the duration of <jats:styled-content style=\"fixed-case\">LSS<\/jats:styled-content> diagnosis; <jats:styled-content style=\"fixed-case\">LSS<\/jats:styled-content> disease; preoperative medication (limaprost, pregabalin, or combined limaprost\/pregabalin; duration); symptoms; preoperative\/postoperative intermittent claudication (<jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>); operation type; and postoperative medication and period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Limaprost, pregabalin, and combined limaprost\/pregabalin were prescribed preoperatively for 43%, 7%, and 5% of patients, respectively. At an average of 21\u00a0months postoperatively, limaprost, pregabalin, and combined therapy were prescribed in 11%, 8%, 4% of patients, respectively. Medication requirement was significantly lower postoperatively than preoperatively (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). Significant risk factors for required postoperative medication were required preoperative medication (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] 3.088, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 1.679 to 5.681]; postoperative period (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.063, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.031 to 1.096); and postoperative <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.868, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.481 to 10.103). A negative impact from postoperative medication was seen in patients who had undergone decompression surgery (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.589, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.377 to 0.918).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, 23% of <jats:styled-content style=\"fixed-case\">LSS<\/jats:styled-content> patients required medication for pain and\/or numbness at 21\u00a0months postoperatively. Significant factors portending required postoperative medication were preoperative medication, longer postoperative period, and postoperative <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>. A negative influence from postoperative medication was seen in patients who had undergone decompression surgery without fusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12653","type":"journal-article","created":{"date-parts":[[2017,10,28]],"date-time":"2017-10-28T00:16:36Z","timestamp":1509149796000},"page":"625-630","source":"Crossref","is-referenced-by-count":4,"title":["Limaprost or Pregabalin: Preoperative and Postoperative Medication for Pain due to Lumbar Spinal Stenosis"],"prefix":"10.1111","volume":"18","author":[{"given":"Yuji","family":"Kasukawa","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan"},{"name":"Akita Spine Group Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohisa","family":"Miyakoshi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan"},{"name":"Akita Spine 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000261029.29170.e6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200405150-00011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200006150-00009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-014-3262-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767010-00010"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1079"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3171\/spi.2005.3.2.0129"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000251014.81875.6d"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4184\/asj.2015.9.3.440"},{"key":"e_1_2_7_11_1","volume-title":"Medical 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non\u2010inferiority trial","volume":"16","author":"Kim HJ","year":"2016","journal-title":"Spine J (Phila Pa 1976)"}],"container-title":["Pain 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