{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T19:04:15Z","timestamp":1788375855644,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"APICIL foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The management of neuropathic pain and pain related to bone vaso\u2010occlusive crises in sickle cell disease remains challenging in children. Lidocaine 5% patches are recommended in adults for neuropathic pain treatment, but they are not recommended in children. The purpose of this study was to assess the efficacy and tolerance of lidocaine 5% patches in pediatric inpatients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, multicenter, single\u2010arm, phase <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> study aimed to assess the use of lidocaine 5% patches in 6\u2010 to 21\u2010year\u2010old pediatric patients suffering from neuropathic pain or superficial bone vaso\u2010occlusive crises. Patches were applied on the painful area for 12 hours a day. The primary endpoint was the proportion of inpatients with significant pain relief defined as a decrease of at least 2 points on the visual analog pain scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>) measured at 12 hours after patch placement over at least 2 consecutive days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 12\u2010hour <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> score decreased by at least 2 points over 2 consecutive days in 48.6% of patients 95% unilateral confidence interval (33.8%). Only 7.7% of patients experienced grade 1 or grade 2 toxicities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although lidocaine 5% patches decreased the pain's intensity in nearly half of the enrolled patients with an excellent tolerance, the efficacy endpoint was not reached. Further studies should consider a more refined selection of the experimental population to assess the efficacy of lidocaine 5% patches in the pediatric population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12674","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T16:13:06Z","timestamp":1513786386000},"page":"788-797","source":"Crossref","is-referenced-by-count":18,"title":["Efficacy and Tolerance of Lidocaine 5% Patches in Neuropathic Pain and Pain Related to Vaso\u2010occlusive Sickle Cell Crises in Children: A Prospective Multicenter Clinical Study"],"prefix":"10.1111","volume":"18","author":[{"given":"Vanessa","family":"Rousseau","sequence":"first","affiliation":[{"name":"Emergency Department and Pediatric Resuscitation Civil Hospitals of Lyon Mother\u2010Child Hospital Bron France"},{"name":"L\u00e9on B\u00e9rard Center Institute of Hematology and Pediatric Oncology Lyon 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