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Conventional\n                    <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content>\n                    is believed mediate pain relief via activation of dorsal column A\u03b2 fibers, resulting in variable effects on sensory and pain thresholds, and measurable alterations in higher order cortical processing. Although potentiation of inhibition, as suggested by Wall and Melzack's gate control theory, continues to be the leading explanatory model, other segmental and supraspinal mechanisms have been described. Novel, non\u2010standard, stimulation waveforms such as high\u2010frequency and burst have been shown in some studies to be clinically superior to conventional\n                    <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content>\n                    , however their mechanisms of action remain to be determined. Additional studies are needed, both mechanistic and clinical, to better understand optimal stimulation strategies for different neuropathic conditions, improve patient selection and optimize efficacy.\n                  <\/jats:p>","DOI":"10.1111\/papr.12692","type":"journal-article","created":{"date-parts":[[2018,3,11]],"date-time":"2018-03-11T04:02:34Z","timestamp":1520740954000},"page":"1048-1067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":356,"title":["Spinal Cord Stimulation: Clinical Efficacy and Potential Mechanisms"],"prefix":"10.1111","volume":"18","author":[{"given":"Andrei D.","family":"Sdrulla","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine Oregon Health &amp; Science University Portland Oregon U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of 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