{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:53:18Z","timestamp":1792806798059,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T00:00:00Z","timestamp":1528675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","award":["ISRNO060009"],"award-info":[{"award-number":["ISRNO060009"]}],"id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Two well\u2010known spinal cord stimulation (<jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content>) paradigms, conventional (Con) and burst <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content>, are hypothesized to exert their antinociceptive effects through different stimulation\u2010induced mechanisms. We studied the course of the behavioral antinociceptive effect during 60\u00a0minutes of <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> and 30\u00a0minutes post\u2010<jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> in a rat model of chronic neuropathic pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Animals underwent a unilateral partial sciatic nerve ligation, after which quadripolar electrodes were implanted into the epidural space at vertebral level T13 (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>43 rats). While receiving either Con <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> or biphasic burst <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content>, the pain behavior of the rats was assessed by means of paw withdrawal thresholds (<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>s) in response to the application of von Frey monofilaments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 15\u00a0minutes of Con <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>21), <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>s significantly differed from baseline (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.04), whereas <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>s of the burst <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> group (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>22) did not. After 30\u00a0minutes of <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> WT<\/jats:styled-content>s of the Con <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> and burst <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> groups reached similar levels, both significantly different from baseline, indicating a comparable antinociceptive effect for these <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> paradigms. Yet, the <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>s of the burst <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> group were still significantly increased compared with baseline at 30\u00a0minutes post\u2010stimulation, whereas the <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>s of the Con <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> group were not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To conclude, biphasic burst <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> results in a delayed antinociceptive effect after onset of the stimulation, as compared with Con <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content>, in a chronic neuropathic pain model. Furthermore, biphasic burst <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> seems to exhibit a delayed wash\u2010out of analgesia after stimulation is turned off.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12701","type":"journal-article","created":{"date-parts":[[2018,4,21]],"date-time":"2018-04-21T03:38:50Z","timestamp":1524281930000},"page":"988-996","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Burst Spinal Cord Stimulation in Peripherally Injured Chronic Neuropathic Rats: A Delayed Effect"],"prefix":"10.1111","volume":"18","author":[{"given":"Koen P. 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