{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:03:42Z","timestamp":1789733022655,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T00:00:00Z","timestamp":1533686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Among the elderly population, chronic osteoarthritis of the knee joint is one of the leading causes of disability and causes considerable pain, joint stiffness, and functional limitations. Although knee replacement is a good option for advanced osteoarthritis, many patients could not undergo surgery due to comorbidities or other reasons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four patients with severe pain from grade 3 and 4 osteoarthritis of the knee had undergone ultrasound\u2010guided alcohol neurolysis of the 6 genicular nerves after a positive genicular nerve block with local anesthetics. The demographics, pain intensity (NRS), Oxford Knee Score (OKS), Western Ontario and McMaster Universities Osteoarthritis Index (<jats:styled-content style=\"fixed-case\">WOMAC<\/jats:styled-content>), and quality of life (SF\u201036) were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was significant improvement in pain intensity at rest, on movement, and on weight bearing after the neurolysis and it has continued for 6 months (<jats:italic>P<\/jats:italic> &lt; 0.05). The OKS and <jats:styled-content style=\"fixed-case\">WOMAC<\/jats:styled-content> score had improved from 7.75\u00a0\u00b1\u00a01.25 and 77.75\u00a0\u00b1\u00a04.34 at baseline, to 20.75\u00a0\u00b1\u00a01.70 and 56.25\u00a0\u00b1\u00a03.09 at 1\u00a0month, and to 18.25\u00a0\u00b1\u00a00.95 and 52.00\u00a0\u00b1\u00a02.16 at 6\u00a0months after the procedure, respectively (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). There was also significant improvement in the quality of life after the procedure (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ultrasound\u2010guided alcohol neurolysis is a good alternative for patients having severe pain from knee osteoarthritis and provides significant pain relief for more than 6\u00a0months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12710","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T01:37:23Z","timestamp":1526348243000},"page":"16-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Ultrasound\u2010Guided Neurolysis of Six Genicular Nerves for Intractable Pain from Knee Osteoarthritis: A Case Series"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0756-1591","authenticated-orcid":false,"given":"Arif","family":"Ahmed","sequence":"first","affiliation":[{"name":"Asian Institute of Medical Sciences Faridabad Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divesh","family":"Arora","sequence":"additional","affiliation":[{"name":"Asian Institute of Medical Sciences Faridabad Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.phm.0000245568.69434.1a"},{"key":"e_1_2_8_3_1","first-page":"1037","article-title":"Physical and psychosocial disability in elderly subjects in relation to pain in the hip and\/or knee","volume":"23","author":"Hopman\u2010Rock M","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.2.91"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2000.tb02597.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21596"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.09.029"},{"key":"e_1_2_8_8_1","first-page":"233","article-title":"Radiofrequency thermocoagulation, a new alternative therapy for genicular nerves in chronic knee osteoarthritis: a pilot study for a new alternative therapy","volume":"62","author":"Sari S","year":"2016","journal-title":"Turk J Phys Med Rehabil"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5603\/AIT.2015.0003"},{"key":"e_1_2_8_10_1","first-page":"8292450","article-title":"Ultrasound\u2010guided genicular nerve thermal radiofrequency ablation for chronic knee pain","volume":"2016","author":"Wong J","year":"2016","journal-title":"Case Rep Anesthesiol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnw177"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj\/2019.19.E751"},{"key":"e_1_2_8_13_1","first-page":"797","volume-title":"Musculoskeletal Ultrasound for Regional Anesthesia and Pain Medicine","author":"Lam SKH","year":"2016"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000269"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000516"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000778"},{"key":"e_1_2_8_17_1","first-page":"E697","article-title":"Is genicular nerve radiofrequency ablation safe? A literature review and anatomical study","volume":"19","author":"Kim SY","year":"2016","journal-title":"Pain Physician"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(78)90009-X"},{"key":"e_1_2_8_19_1","first-page":"392","volume-title":"Interventional Pain Management","author":"Raj PP","year":"1996"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpapr.12710","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.12710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T10:28:41Z","timestamp":1694687321000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.12710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,8]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/papr.12710"],"URL":"https:\/\/doi.org\/10.1111\/papr.12710","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,8]]},"assertion":[{"value":"2017-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}