{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:42:06Z","timestamp":1750380126205},"reference-count":6,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T00:00:00Z","timestamp":1540684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Despite being reported since 1943 as well as being the subject of a large body of literature since that time, no consensus has been reached regarding the etiology of opioid induced hyperalgesia (<jats:styled-content style=\"fixed-case\">OIH<\/jats:styled-content>). It is often described as a paradoxical increased pain response to noxious stimuli due to increased sensitization or an acute tolerance to opioids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>We report the case of a 60 year old patient on chronic Intrathecal combined fentanyl and Bupivacaine who had worsening pain with increasing doses and improved after weaning off intrathecal opioids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">OIH<\/jats:styled-content> has been described in various settings including patients on methadone maintenance therapy, perioperative opioid administration, cancer patients on opioids, and healthy volunteers who are acutely exposed to opioids, including high dose intrathecal opioids such as Morphine and Sufentanil. To our knowledge, no cases of opioid induced hyperalgesia was previously reported in the case of intrathecal Fentanyl.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12726","type":"journal-article","created":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T17:02:57Z","timestamp":1538240577000},"page":"222-223","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Opioid Induced Hyperalgesia with Intrathecal Infusion of High\u2010Dose Fentanyl"],"prefix":"10.1111","volume":"19","author":[{"given":"Antranig","family":"Kalaydjian","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Critical Care &amp; Pain Medicine St Elizabeth Medical Center Boston Massachusetts U.S.A"},{"name":"Tufts University School of Medicine Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadi","family":"Farah","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care &amp; Pain Medicine St Elizabeth Medical Center Boston Massachusetts U.S.A"},{"name":"Tufts University School of Medicine Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care &amp; Pain Medicine St Elizabeth Medical Center Boston Massachusetts U.S.A"},{"name":"Tufts University School of Medicine Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin A.","family":"Acquadro","sequence":"additional","affiliation":[{"name":"Anesthesiology Tufts University School of Medicine Boston Massachusetts U.S.A"},{"name":"Department of Anesthesiology, Critical Care &amp; Pain Medicine St. Elizabeth's Pain Management Center Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic J.","family":"Gerges","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine Boston Massachusetts U.S.A"},{"name":"Department of Anesthesiology, Critical Care &amp; Pain Medicine St. Elizabeth's Pain Management Center Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101420"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(91)90225-M"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/104990910302000608"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008506-199704000-00007"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-018-0094-9"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","unstructured":"S\u00f8rensenJ Sj\u00f8grenP.Opioid\u2010induced hyperalgesia. In:HannaM ZyliczZ eds.Cancer Pain.London:Springer;2013:131\u2013142.","DOI":"10.1007\/978-0-85729-230-8_10"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpapr.12726","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.12726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T18:40:35Z","timestamp":1694716835000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.12726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,28]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/papr.12726"],"URL":"https:\/\/doi.org\/10.1111\/papr.12726","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,28]]},"assertion":[{"value":"2018-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}