{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:49:33Z","timestamp":1765079373552},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400372","81460092","81660158"],"award-info":[{"award-number":["81400372","81460092","81660158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Neuroimaging studies have shown that patients with pain\u2010related conditions have altered neuronal activity and structural functions. The purpose of this study was to investigate whether patients with classical trigeminal neuralgia (<jats:styled-content style=\"fixed-case\">CTN<\/jats:styled-content>) exhibit changes in corresponding neuronal activity via analysis of neuronal activity regional homogeneity (ReHo).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 28 patients presenting with sore eyes (12 men and 16 women) were matched with 28 healthy controls (12 men and 16 women). All participants underwent functional magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content>). This ReHo method was used to assess the consistency of changes in neural activity in various brain regions. The receiver operating characteristic (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) curve was applied to differentiate ReHo values of patients with <jats:styled-content style=\"fixed-case\">CTN<\/jats:styled-content> from ReHo values of healthy controls. Pearson's correlation analysis was applied to evaluate the correlation between ReHo values of different brain regions of patients with <jats:styled-content style=\"fixed-case\">CTN<\/jats:styled-content> and clinical manifestations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with healthy controls, patients with <jats:styled-content style=\"fixed-case\">CTN<\/jats:styled-content> were found to have increased ReHo values in the inferior cerebellum bilaterally, right inferior temporal gyrus, right middle occipital gyrus, right fusiform gyrus, right superior frontal gyrus, and right precentral gyrus. <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve analysis of each brain region revealed near\u2010perfect accuracy regarding the area under the curve. However, no correlation between ReHo values and clinical manifestations in patients with <jats:styled-content style=\"fixed-case\">CTN<\/jats:styled-content> was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CTN<\/jats:styled-content> is associated with altered neuronal networks in different areas of the brain. ReHo values all possess different degrees of change, implying that <jats:styled-content style=\"fixed-case\">CTN<\/jats:styled-content> has a certain impact on cerebral function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12753","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T11:53:16Z","timestamp":1544529196000},"page":"397-406","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Altered Spontaneous Brain Activity in Patients with Classical Trigeminal Neuralgia Using Regional Homogeneity: A Resting\u2010State Functional <scp>MRI<\/scp> Study"],"prefix":"10.1111","volume":"19","author":[{"given":"Chu\u2010Qi","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center Nanchang Jiangxi 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