{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:31:00Z","timestamp":1791909060857,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Research Foundation for Microbial Diseases of Osaka University"},{"name":"Japanese Ministry of Health, Labour and Welfare","award":["KHC1102"],"award-info":[{"award-number":["KHC1102"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>There have been no community\u2010based studies investigating the association between sleep duration and postherpetic neuralgia (<jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content>) development. The aim of the current study was to examine the association of sleep with herpes zoster (<jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>) incidence and <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 12,329 residents (ages 50 to 103\u00a0years) of Shozu County, Japan, participated in our study from December 2009 to November 2010 and were followed up for 3\u00a0years. At baseline, the participants completed self\u2010administered health questionnaires, including those on usual sleep duration. Three dermatologists diagnosed <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> on the basis of clinical symptoms and virus identification testing by polymerase chain reaction and serological tests, and evaluated pain using a modified Zoster Brief Pain Inventory survey form via telephone. We used a Cox proportional hazard regression model to estimate hazard ratios (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>s) and 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) of incident <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content>. We also performed mediation analysis to examine whether hyperesthesia and acute pain intensity mediated the association between sleep shortage and chronic pain intensity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During follow\u2010up, 400 cases of <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> were identified. Of these, 55 participants developed <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content>. Sleep duration was not associated with <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> incidence. Sleep shortage increased the risk for <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 2.02 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.06 to 3.85]). Hyperesthesia and acute pain intensity mediated the association between sleep shortage and chronic pain intensity (indirect\/total effect ratio\u00a0=\u00a050% mediation).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sleep shortage was associated with increased risk for <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content>, and hyperesthesia and acute pain intensity appeared to mediate this association. Sleep shortage may be a novel risk factor for <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12766","type":"journal-article","created":{"date-parts":[[2019,1,19]],"date-time":"2019-01-19T20:13:21Z","timestamp":1547928801000},"page":"476-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Sleep Shortage Is Associated With Postherpetic Neuralgia Development Through Hyperesthesia and Acute Pain Intensity: A Community\u2010Based Prospective Cohort Study"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4378-3290","authenticated-orcid":false,"given":"Keiko","family":"Yamada","sequence":"first","affiliation":[{"name":"Public Health, Department of Social Medicine Osaka University Graduate School of Medicine Suita Osaka Japan"},{"name":"Department of Anesthesiology and Pain Medicine Juntendo University Faculty of 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Graduate School of Medicine Kobe Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Okuno","sequence":"additional","affiliation":[{"name":"The Research Foundation for Microbial Diseases of Osaka University Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Asada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nara Medical University School of Medicine Kashihara Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Yamanishi","sequence":"additional","affiliation":[{"name":"National Institute of Biomedical Innovation Ibaraki Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyasu","family":"Iso","sequence":"additional","affiliation":[{"name":"Public Health, Department of Social Medicine Osaka University Graduate School of Medicine Suita Osaka 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