{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:32:18Z","timestamp":1780320738122,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the efficacy and safety of ultrasound\u2010guided cervical nerve root block (CRB) on acute pain and its preventive effects on post\u2010herpetic neuralgia (PHN) in patients with cervical herpes zoster (HZ).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>140 recruited participants were randomized 1:1 to receive ultrasound\u2010guided CRB with either mixed drug liquid (treatment group) or similar looking placebo (placebo group). All patients received a 7\u2010day course of oral antiviral treatment, pregabalin, and analgesics as needed. The primary efficacy was assessed on the basis of HZ burden of illness (HZ\u2010BOI) scores over 30\u00a0days (BOI\u201030<jats:sub>AUC<\/jats:sub>). Secondary outcomes included HZ\u2010BOI scores through 30 to 90\u00a0days (BOI\u201030\u201090<jats:sub>AUC<\/jats:sub>) and 90 to 180\u00a0days (BOI\u201090\u2010180<jats:sub>AUC<\/jats:sub>), quality of life (QoL) outcomes, concomitant analgesic consumption, and the incidence of PHN. Adverse events were recorded to evaluate safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The BOI\u201030<jats:sub>AUC<\/jats:sub> values were 92.55 and 112.72 for the treatment and placebo groups, respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Both the BOI\u201030\u201090<jats:sub>AUC<\/jats:sub> and BOI\u201090\u2010180<jats:sub>AUC<\/jats:sub> in the treatment group were lower than those in the placebo group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). The incidence of PHN at 90\u00a0days was significantly less than that at 180\u00a0days in the treatment group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.036). A better improvement in QoL was found in the treatment group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). There was a greater decrease in analgesic use in the treatment group as compared to the placebo group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). No serious adverse events were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ultrasound\u2010guided CRB represented an early intervention and preventive strategy to reduce the BOI due to acute HZ in the cervical dermatome region, and might be feasible to reduce the incidence of PHN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12770","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T03:34:05Z","timestamp":1549596845000},"page":"500-509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ultrasound\u2010Guided Cervical Nerve Root Block for the Treatment of Acute Cervical Herpes Zoster: A Randomized Controlled Clinical Study"],"prefix":"10.1111","volume":"19","author":[{"given":"Shuyue","family":"Zheng","sequence":"first","affiliation":[{"name":"Pain Clinic of Anesthesiology Department Central Hospital of China Aerospace Corporation (Aerospace Clinical Medical School of Peking University) Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pain Management Tsinghua University YuQuan Hospital (Second Hospital of Tsinghua University) Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Yang","sequence":"additional","affiliation":[{"name":"Pain Clinic of Anesthesiology Department Central Hospital of China Aerospace Corporation (Aerospace Clinical Medical School of Peking University) Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pain Management Xuanwu Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of 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