{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:25:15Z","timestamp":1782210315087,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T00:00:00Z","timestamp":1563494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic abdominal pain can be due to entrapped intercostal nerves (anterior cutaneous nerve entrapment syndrome [<jats:styled-content style=\"fixed-case\">ACNES<\/jats:styled-content>]). If abdominal wall infiltration using an anesthetic agent is unsuccessful, a neurectomy may be considered. Pulsed radiofrequency (<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>) applies an electric field around the tip of the cannula near the affected nerve to induce pain relief. Only limited retrospective evidence suggests that <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> is effective in <jats:styled-content style=\"fixed-case\">ACNES<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter, randomized, nonblinded, controlled proof\u2010of\u2010concept trial was performed in 66 patients. All patients were scheduled for a neurectomy procedure. Thirty\u2010three patients were randomized to first receive a 6\u2010minute cycle of <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> treatment, while the other 33 were allocated to an immediate neurectomy procedure. Pain was recorded using a numeric rating scale (<jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content>, 0 [no pain] to 10 [worst pain possible]). Successful treatment was defined as &gt;50% pain reduction. Patients in the <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> group were allowed to cross over to a neurectomy after 8\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The neurectomy group showed greater pain reduction at 8\u2010week follow\u2010up (mean change from baseline \u22122.8 (95% confidence interval [CI] \u22123.9 to \u22121.7) vs. \u22121.5 (95% CI \u22122.3 to \u22120.6); <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.045) than the <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> group. Treatment success was reached in 12 of 32 (38%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 23 to 55) of the <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> group and 17 of 28 (61%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 42 to 72) of the neurectomy group (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.073). Thirteen patients were withdrawn from their scheduled surgery. Adverse events were comparable between treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> appears to be an effective and minimally invasive treatment option and may therefore be considered in patients who failed conservative treatment options before proceeding to a neurectomy procedure. Anterior neurectomy may possibly lead to a greater pain relief compared with <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">ACNES<\/jats:styled-content>, but potential complications associated with surgery should be discussed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12806","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T12:43:00Z","timestamp":1560343380000},"page":"751-761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["A Randomized Controlled Trial to Evaluate the Effect of Pulsed Radiofrequency as a Treatment for Anterior Cutaneous Nerve Entrapment Syndrome in Comparison to Anterior Neurectomy"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5352-0646","authenticated-orcid":false,"given":"Robbert C.","family":"Maatman","sequence":"first","affiliation":[{"name":"Department of Surgery M\u00e1xima Medical Center Veldhoven The Netherlands"},{"name":"SolviM\u00e1x Center of Expertise for ACNES Center of Excellence for Chronic Abdominal Wall and Groin Pain M\u00e1xima Medical Center Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander M.J.","family":"van Kuijk","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Medical Technology Assessment (KEMTA) MUMC+ Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique A.H.","family":"Steegers","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology &amp; Pain and Palliative Care Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver B.A.","family":"Boelens","sequence":"additional","affiliation":[{"name":"Department of Surgery Maas Pantein Hospital Boxmeer The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toine C.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology &amp; Pain and Palliative Care M\u00e1xima Medical Centre Veldhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R.M.","family":"Scheltinga","sequence":"additional","affiliation":[{"name":"Department of Surgery M\u00e1xima Medical Center Veldhoven The Netherlands"},{"name":"SolviM\u00e1x Center of Expertise for ACNES Center of Excellence for Chronic Abdominal Wall and Groin Pain M\u00e1xima Medical Center Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudi M.H.","family":"Roumen","sequence":"additional","affiliation":[{"name":"Department of Surgery M\u00e1xima Medical Center Veldhoven The Netherlands"},{"name":"SolviM\u00e1x Center of Expertise for ACNES Center of Excellence for Chronic Abdominal Wall and Groin Pain M\u00e1xima Medical Center Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,19]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"329","article-title":"Microanatomy of the structures contributing to abdominal cutaneous nerve entrapment syndrome","volume":"10","author":"Applegate WV","year":"1997","journal-title":"J Am Board Fam Pract."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tria.2017.10.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13049-015-0096-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199204000-00004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05662.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31822d78b8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02170.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2005.00744.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8958"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.05.022"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318285f930"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2006.05.018"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1024\/1023-9332.7.2.82"},{"key":"e_1_2_9_15_1","first-page":"109","article-title":"The effect of pulsed radiofrequency fields applied to the dorsal root ganglion","volume":"1998","author":"Sluijter ME","year":"1998","journal-title":"Pain Clin."},{"key":"e_1_2_9_16_1","first-page":"109","article-title":"The effects of pulsed radiofrequency fields applied to the dorsal ganglia\u2014a preliminary report","volume":"11","author":"Sluijter ME","year":"1998","journal-title":"Pain Clin."},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-004-0038-4"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.09.002"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12670"},{"key":"e_1_2_9_20_1","first-page":"15","article-title":"Efficacy of pulsed radiofrequency in the treatment of thoracic postherpetic neuralgia from the angulus costae: a randomized, double\u2010blinded, controlled trial","volume":"16","author":"Ke M","year":"2013","journal-title":"Pain Physician."},{"key":"e_1_2_9_21_1","first-page":"E147","article-title":"Pulsed radiofrequency for chronic inguinal neuralgia","volume":"18","author":"Makharita MY","year":"2015","journal-title":"Pain Physician."},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2014.03.010"},{"key":"e_1_2_9_23_1","first-page":"E443","article-title":"Pulsed radiofrequency for chronic abdominal pain","volume":"16","author":"Birthi P","year":"2013","journal-title":"Pain Physician."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr3354w"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-2110-5"},{"key":"e_1_2_9_26_1","first-page":"e60","article-title":"CONSORT 2010 Statement: updated guidelines for reporting parallel group randomized trials","volume":"4","author":"Schulz KF","year":"2010","journal-title":"Open Med."},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198410000-00010"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.08.019"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00109-7"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9993(91)90012-8"},{"key":"e_1_2_9_31_1","first-page":"129","article-title":"Pain assessment: global use of the Brief Pain Inventory","volume":"23","author":"Cleeland CS","year":"1994","journal-title":"Ann Acad Med Singapore."},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-199209000-00004"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2009.01.005"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.12.010"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-014-2737-2"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e3181c76c21"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-010-0881-5"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjpain.2012.05.071"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2009.00770.x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1529-9430(03)00065-2"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000373"},{"key":"e_1_2_9_42_1","first-page":"227","article-title":"Pulsed radiofrequency of the dorsal root ganglia is superior to pharmacotherapy or pulsed radiofrequency of the intercostal nerves in the treatment of chronic postsurgical thoracic pain","volume":"9","author":"Cohen SP","year":"2006","journal-title":"Pain Physician."},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.151113"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2013\/16\/E601"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnx343"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10029-017-1710-z"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-211-27458-8_32"},{"key":"e_1_2_9_48_1","first-page":"45","article-title":"Myofascial pain syndrome in the differential diagnosis of chronic abdominal pain","volume":"16","author":"Cimen A","year":"2004","journal-title":"Agri."},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.06.025"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1155\/2005\/274181"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000160"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.12806","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/papr.12806","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.12806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T18:46:41Z","timestamp":1693421201000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.12806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,19]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/papr.12806"],"URL":"https:\/\/doi.org\/10.1111\/papr.12806","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,19]]},"assertion":[{"value":"2019-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}