{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:07:00Z","timestamp":1791266820661,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Topical capsaicin is commonly employed to experimentally induce central sensitization (<jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>) in humans. While previous studies have investigated the effect of skin preheating on the sensitizing effect of capsaicin, no studies have compared the synergistic effect of skin preheating on the magnitude of sensitization via topical capsaicin within the first 30\u00a0minutes of application. We tested the hypothesis that skin preheating potentiates the sensitizing effect of topical capsaicin by evoking a larger region of secondary hyperalgesia vs. topical capsaicin alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty young, healthy subjects each received topical capsaicin (Zostrix <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content> 0.075%) only (<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>), topical capsaicin with preheating (<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">HEAT<\/jats:styled-content>), and topical nonsensitizing placebo cream (<jats:styled-content style=\"fixed-case\">CON<\/jats:styled-content>) in a crossover design. Capsaicin and placebo creams were applied to a 50\u00a0cm<jats:sup>2<\/jats:sup> area of the dorsal forearm. The <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">HEAT<\/jats:styled-content> session also included a 10\u2010minute preheating session. Regions of secondary hyperalgesia were assessed using mechanical brush allodynia testing, and skin temperature was assessed via infrared thermography. Outcomes were normalized to baseline and compared at 10, 20, and 30\u00a0minutes after cream application.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">HEAT<\/jats:styled-content> session led to a significantly larger area of secondary hyperalgesia compared to the <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> session as measured by brush allodynia (<jats:styled-content style=\"fixed-case\">CON<\/jats:styled-content>: 0\u00a0\u00b1\u00a00 cm; <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>: 2.08\u00a0\u00b1\u00a00.45 cm; <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">HEAT<\/jats:styled-content>: 3.70\u00a0\u00b1\u00a00.46\u00a0cm; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and skin temperature (<jats:styled-content style=\"fixed-case\">CON<\/jats:styled-content>: \u22122.92%\u00a0\u00b1\u00a00.03%; <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>: \u22120.63%\u00a0\u00b1\u00a00.09%; <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">HEAT<\/jats:styled-content>: 2.50%\u00a0\u00b1\u00a00.11%; ( of baseline) <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preheating amplifies the sensitizing effect of topical capsaicin within 30\u00a0minutes of application. The heat\u2013capsaicin technique may be employed to assess differing magnitudes of <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> induction and enables future studies investigating the development and progression of <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> in humans.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12811","type":"journal-article","created":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T07:54:09Z","timestamp":1561362849000},"page":"811-820","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Acute Effect of Skin Preheating on Capsaicin\u2010Induced Central Sensitization in Humans"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5180-4904","authenticated-orcid":false,"given":"Lukas D.","family":"Linde","sequence":"first","affiliation":[{"name":"Department of Human Health and Nutritional Sciences University of Guelph 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