{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:30Z","timestamp":1787015850399,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T00:00:00Z","timestamp":1566604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2020,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Musculoskeletal conditions are well documented in inflammatory bowel disease (\n IBD<\/jats:styled-content>\n ). However, whether\n IBD<\/jats:styled-content>\n activity influences musculoskeletal pain experiences is uncertain. Central sensitization has been proposed in patients with\n IBD<\/jats:styled-content>\n who are suffering from persistent pain. Identification of central sensitization symptomology using the Central Sensitization Inventory (\n CSI<\/jats:styled-content>\n ) has been reported in many pain\u2010related disorders. Aims of this study were to explore predictive relationships between\n IBD<\/jats:styled-content>\n activity and musculoskeletal pain experiences (severity\/interference), and the mediating effects of the\n CSI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A cross\u2010sectional online survey was performed exploring self\u2010reported musculoskeletal pain in adults with\n IBD<\/jats:styled-content>\n . Survey questionnaires included\n IBD<\/jats:styled-content>\n activity indices, numeric rating scales,\n PROMIS<\/jats:styled-content>\n Pain Interference, and the\n CSI<\/jats:styled-content>\n . Linear regression was used to examine the relationship between active\n IBD<\/jats:styled-content>\n and pain experiences. Simple and serial mediation analyses were used to explore mediation models: independent variable (\n IBD<\/jats:styled-content>\n activity), dependent variables (severity\/interference), and mediators (\n CSI<\/jats:styled-content>\n \/severity).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n 208 adults with\n IBD<\/jats:styled-content>\n , 18 to 88\u00a0years of age, reported musculoskeletal pain. Regression analysis identified\n IBD<\/jats:styled-content>\n activity as a significant predictor of worse pain severity (\n R<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a00.039,\n P<\/jats:italic>\n \u00a0<\u00a00.005) and interference (\n R<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a00.067,\n P<\/jats:italic>\n \u00a0<\u00a00.001). Simple mediation showed a significant indirect effect from\n CSI<\/jats:styled-content>\n scores between\n IBD<\/jats:styled-content>\n activity and pain severity. Serial mediation analysis showed a significant indirect effect from\n CSI<\/jats:styled-content>\n scores and pain severity, between\n IBD<\/jats:styled-content>\n activity and pain interference.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Active\n IBD<\/jats:styled-content>\n demonstrated a positive association with worse musculoskeletal pain experiences. The\n CSI<\/jats:styled-content>\n demonstrated significant mediation between active\n IBD<\/jats:styled-content>\n and pain severity. Additionally, the\n CSI<\/jats:styled-content>\n and pain severity demonstrated significant mediation between active\n IBD<\/jats:styled-content>\n and pain interference. This suggests that symptoms of central sensitization significantly influence musculoskeletal pain experiences in\n IBD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/papr.12821","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T13:54:13Z","timestamp":1563458053000},"page":"24-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Central Sensitization Inventory Mediates the Relationship Between Inflammatory Bowel Disease Activity and Worse Musculoskeletal Pain Experiences"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7985-9349","authenticated-orcid":false,"given":"Carrie L.","family":"Falling","sequence":"first","affiliation":[{"name":"School of Physiotherapy University of Otago Dunedin New 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