{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T04:30:42Z","timestamp":1769747442445,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T00:00:00Z","timestamp":1571356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We sought to refine a screening measure for discriminating a sensitized or normal sensation pain phenotype among African American adults with sickle cell disease (SCD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To develop scoring schemes based on sensory pain quality descriptors; evaluate their performance on classifying patients with SCD who had sensitization or normal sensation, and compare with scores on the Self\u2010report Leeds Assessment of Neuropathic Symptoms and Signs (S\u2010LANSS) and the Neuropathic Pain Symptom Inventory (NPSI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants completed PAIN<jats:italic>Report<\/jats:italic>It, quantitative sensory testing (QST), S\u2010LANSS, and NPSI. Conventional binary logistic regression and least absolute shrinkage and selection operator (lasso) regression were used to obtain 2 sets of weights resulting in 2 scores: the PR\u2010Logistic (PAIN<jats:italic>Report<\/jats:italic>It score weighted by conventional binary logistic regression coefficients) and PR\u2010Lasso (PAIN<jats:italic>Report<\/jats:italic>It score weighted by lasso regression coefficients). Performance of the proposed scores and the existing scores were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lasso regression resulted in a parsimonious model with non\u2010zero weights assigned to 2 neuropathic descriptors, cold and spreading. We found positive correlations between the PR\u2010Lasso and other scores: S\u2010LANSS (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.22, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01), NPSI (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.22, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01), and PR\u2010Logistic (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.35, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01). The NPSI and PR\u2010Lasso performed similarly at different levels of required specificity and outperformed the S\u2010LANSS and PR\u2010Logistic at the various specificity points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The PR\u2010Lasso offers a way to discriminate a SCD pain phenotype.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12841","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T22:16:29Z","timestamp":1569449789000},"page":"168-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A QST\u2010based Pain Phenotype in Adults With Sickle Cell Disease: Sensitivity and Specificity of Quality Descriptors"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4700-321X","authenticated-orcid":false,"given":"Brenda W.","family":"Dyal","sequence":"first","affiliation":[{"name":"Department of Biobehavioral Nursing Science College of Nursing University of Florida Gainesville Florida U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam O.","family":"Ezenwa","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Nursing Science College of Nursing University of Florida Gainesville Florida U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saunjoo L.","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Nursing Science College of Nursing University of Florida Gainesville Florida U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger B.","family":"Fillingim","sequence":"additional","affiliation":[{"name":"Department of Community Dentistry and Behavioral Science University of Florida Gainesville Florida U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingwei","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Nursing Science College of Nursing University of Florida Gainesville Florida U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith M.","family":"Schlaeger","sequence":"additional","affiliation":[{"name":"Department of Women, Children and Family Health Science University of Illinois at Chicago Chicago Illinois U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie L.","family":"Suarez","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Health Science College of Nursing University of Illinois at Chicago Chicago Illinois U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaijie J.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutical Sciences College of Pharmacy University of Illinois at Chicago Chicago Illinois U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert 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