{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:30:09Z","timestamp":1784860209663,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:00:00Z","timestamp":1588723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the efficacy and safety between leucocyte\u2010rich platelet\u2010rich plasma (LR\u2010PRP) and corticosteroid in fluoroscopically guided caudal epidural injection for patients with complex chronic lumbar spinal pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A prospective randomized controlled double\u2010blinded study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty eligible patients with complex chronic degenerative spinal pain were randomly assigned with a 1:1 allocation ratio to receive caudal epidural injection of corticosteroid (triamcinolone acetonide, 60\u00a0mg) or LR\u2010PRP (isolated from 60\u00a0mL autologous blood) under fluoroscopic guidance. Levels of low back pain, quality of life, and complications (or adverse effects) were evaluated at 1, 3, and 6\u00a0months after treatment. Pain levels and quality of life were assessed using the VAS and Short Form 36\u2010Item Health Survey (SF\u201036), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant difference was shown at baseline between the 2 groups. Compared with the pretreatment values, there were significant reductions in the VAS score in both groups. A significantly lower VAS score at 1\u2010month follow\u2010up was detected in patients who received corticosteroid injection. However, the scores were lower in the LR\u2010PRP group at 3\u2010 and 6\u2010month follow\u2010up. SF\u201036 responses at 6 months showed significant improvement in all domains in the LR\u2010PRP group. There were no complications or adverse effects related to treatment at 6\u2010month follow\u2010up in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both autologous LR\u2010PRP and corticosteroid for caudal epidural injections under fluoroscopic guidance are equally safe and therapeutically effective in patients with complex chronic lumbar spinal pain. However, LR\u2010PRP is superior to corticosteroid for a longer pain\u2010relieving effect and improvement in quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12893","type":"journal-article","created":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T10:13:05Z","timestamp":1586254385000},"page":"639-646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["A Randomized Double\u2010Blind Controlled Pilot Study Comparing Leucocyte\u2010Rich Platelet\u2010Rich Plasma and Corticosteroid in Caudal Epidural Injection for Complex Chronic Degenerative Spinal Pain"],"prefix":"10.1111","volume":"20","author":[{"given":"Ricardo","family":"Ruiz\u2010Lopez","sequence":"first","affiliation":[{"name":"Clinica Vertebra, Barcelona Spine and Pain Surgery Center, Unit of MISS Barcelona 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