{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T22:51:03Z","timestamp":1774133463748,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the influence of clinical, psychological, and psychophysical variables on treatment outcomes after application of exercise combined with education with\/without manual therapy in people with tinnitus associated with temporomandibular disorder (TMD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A secondary analysis of a clinical trial was performed investigating the effectiveness of including cervico\u2010mandibular manual therapy into an exercise combined with education program in 61 subjects with TMD\u2010related tinnitus. Clinical outcomes including tinnitus severity and tinnitus\u2010related handicap were assessed at 3 and 6\u00a0months post\u2010intervention. Patients were assessed at baseline for clinical (tinnitus severity, tinnitus\u2010related handicap, quality of life), physical (range of motion), psychological (depression), and psychophysical (pressure pain thresholds [PPTs]) variables that were included as predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The regression models indicated that higher scores of tinnitus severity at baseline predicted better outcomes 3 and 6\u00a0months post\u2010intervention (explaining 13% to 41% of the variance) in both groups. Higher scores of tinnitus\u2010related handicap at baseline predicted better outcome of tinnitus\u2010related handicap (45% variance) in the manual therapy with exercise\/education group. Lower PPTs over the temporalis muscle at baseline predicted poorer clinical outcomes (10.5% to 41% of the variance) in both groups. Other predictors were sex and quality of life (6.7% variance) in the manual therapy group and PPTs over the masseter muscle (5.8% variance) in the exercise\/education group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study found that baseline tinnitus severity and localized PPT over the temporalis muscle were predictive of clinical outcomes in individuals with TMD\u2010related tinnitus following physical therapy. Other predictors (eg, sex, quality of life) were less influential.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12919","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T08:50:45Z","timestamp":1589791845000},"page":"8-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Influence of Clinical, Physical, Psychological, and Psychophysical Variables on Treatment Outcomes in Somatic Tinnitus Associated With Temporomandibular Pain: Evidence From a Randomized Clinical Trial"],"prefix":"10.1111","volume":"21","author":[{"given":"Gustavo","family":"Plaza\u2010Manzano","sequence":"first","affiliation":[{"name":"Department of Radiology, Rehabilitation and Physiotherapy Universidad Complutense de Madrid Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos Madrid 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