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As the situation continues, the need to reinstate attention for patients with chronic pain grows. The restoration of this activity has to begin with on\u2010site appointments and possible surgical procedures. On\u2010site clinical activity has to guarantee the safety of patients and health workers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this review was to evaluate how to manage activity in pain units, considering the scenario generated by the pandemic and the implications of chronic pain on the immune system and proposed pharmacological and interventional therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Besides the established general recommendations (physical distance, surgical masks, gloves, etc.), we established specific recommendations that will allow patient treatment and relieve the disruption of the immune response. It is important to highlight the use of opioids with the least influence in the immune system. Further, individualized corticoid use, risk assessment, reduced immune suppression, and dose adjustment should take patient needs into account. In this scenario, we highlight the use of radiofrequency and neuromodulation therapies, techniques that do not interfere with the immune response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We describe procedures to implement these recommendations for individual clinical situations, the therapeutic possibilities and safety guidelines for each center, and government recommendations during the COVID\u201019 pandemic.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12951","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T07:56:28Z","timestamp":1600934188000},"page":"820-828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["How to Restart the Interventional Activity in the COVID\u201019 Era: The Experience of a Private Pain Unit in Spain"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4654-667X","authenticated-orcid":false,"given":"David","family":"Abej\u00f3n","sequence":"first","affiliation":[{"name":"Pain Management Unit Hospital Universitario Quir\u00f3nsalud Madrid Hospital Quir\u00f3nsalud San Jos\u00e9 Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5101-1058","authenticated-orcid":false,"given":"Eva M.","family":"Monz\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Universitario Quir\u00f3nsalud Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8907-7730","authenticated-orcid":false,"given":"Tim","family":"Deer","sequence":"additional","affiliation":[{"name":"Spine and Nerve Center of the Virginias Charleston West Virginia U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1039-8166","authenticated-orcid":false,"given":"Jonathan M.","family":"Hagedorn","sequence":"additional","affiliation":[{"name":"Division of Pain Medicine Department of Anesthesiology and Perioperative Medicine Mayo Clinic Rochester Minnesota U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3161-4825","authenticated-orcid":false,"given":"Ricardo","family":"Araujo","sequence":"additional","affiliation":[{"name":"Instituto Aliaga Cl\u00ednica Teknon Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6878-4735","authenticated-orcid":false,"given":"Cristina","family":"Abad","sequence":"additional","affiliation":[{"name":"Pain Management Department Hospital Universitario Quir\u00f3nsalud Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1305-5038","authenticated-orcid":false,"given":"Alberto","family":"Rios","sequence":"additional","affiliation":[{"name":"Pain Management Department Hospital Universitario Quir\u00f3nsalud Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4804-163X","authenticated-orcid":false,"given":"Alejandro","family":"Zamora","sequence":"additional","affiliation":[{"name":"Pain Management Department Hospital Universitario Quir\u00f3nsalud Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Vallejo","sequence":"additional","affiliation":[{"name":"National Spine and Pain Centers Rockville MD U.S.A."},{"name":"Psychology Department Illinois Wesleyan University Bloomington Illinois U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnaa127"},{"key":"e_1_2_8_3_1","unstructured":"European Centre for Disease Prevention and Control.COVID\u201019.https:\/\/www.ecdc.europa.eu\/en\/covid\u201019\u2010pandemic(accessed October 4 2020)."},{"key":"e_1_2_8_4_1","unstructured":"World Health Organization.Coronavirus disease (COVID\u201019) outbreak.2020.https:\/\/www.who.int\/emergencies\/diseases\/novel\u2010coronavirus\u20102019(accessed October 4 2020)."},{"volume-title":"Features, evaluation and treatment coronavirus (COVID\u201019)","year":"2020","author":"Cascella M","key":"e_1_2_8_5_1"},{"key":"e_1_2_8_6_1","unstructured":"Centers for Disease Control and Prevention.Strategies for optimizing the supply of facemasks. 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