{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T21:39:24Z","timestamp":1755034764166,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T00:00:00Z","timestamp":1603584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Scientific data about neurophysiological changes subsequent to pulsed radiofrequency (PRF) are still lacking. The goal of this study was to evaluate sural nerve conduction and Hoffmann reflex (H\u2010reflex) in soleus muscle following adhesiolysis and PRF in patients with unilateral chronic lumbosacral L5\u2010S1 neuropathic radiating pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventeen patients received two cycles of 240\u00a0seconds high\u2010voltage PRF and epidural adhesiolysis. Sural nerve action potential (SNAP) and the ratio of maximum H\u2010reflex to maximum M response (H\/M ratio) as well as pain scores were collected in both lower limbs before, immediately following, and 1\u00a0month after the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At follow\u2010up, a significant reduction in numeric rating scale (NRS) and Douleur Neuropathique 4 Questions (DN4) scores was observed in 53% of patients reporting pain improvement of \u2265\u00a030% over baseline. The H\/M ratio was decreased in the affected limb following PRF (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) and 1\u00a0month after the treatment (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). A direct correlation was observed between H\/M ratio variation and NRS score at follow\u2010up in the treated limb (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). No significant difference in sural nerve latency, amplitude, and velocity was detected between affected and normal side after treatment and at follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Epidural adhesiolysis and PRF of the dorsal root ganglion seem to significantly affect spinal reflexes in patients with lumbosacral neuropathic radiating pain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12955","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T18:54:03Z","timestamp":1600973643000},"page":"277-284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010term Inhibition of Soleus H\u2010reflex with Epidural Adhesiolysis and Pulsed Radiofrequency in Lumbosacral Neuropathic Pain"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6511-3490","authenticated-orcid":false,"given":"Simone","family":"Vigneri","sequence":"first","affiliation":[{"name":"Pain Medicine Department Santa Maria Maddalena Hospital  Occhiobello Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Sindaco","sequence":"additional","affiliation":[{"name":"Pain Medicine Department Santa Maria Maddalena Hospital  Occhiobello Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"La Grua","sequence":"additional","affiliation":[{"name":"Pain Medicine Department Santa Maria Maddalena Hospital  Occhiobello Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Zanella","sequence":"additional","affiliation":[{"name":"Pain Medicine Department Santa Maria Maddalena Hospital  Occhiobello Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Paci","sequence":"additional","affiliation":[{"name":"Pain Medicine Department Santa Maria Maddalena Hospital  Occhiobello Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca Maria","family":"Vinci","sequence":"additional","affiliation":[{"name":"Pain Medicine Department Santa Maria Maddalena Hospital  Occhiobello Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Sciacca","sequence":"additional","affiliation":[{"name":"Pain Medicine Department Santa Maria Maddalena Hospital  Occhiobello Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Merlini","sequence":"additional","affiliation":[{"name":"Pain Medicine Department Santa Maria Maddalena Hospital  Occhiobello Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilberto","family":"Pari","sequence":"additional","affiliation":[{"name":"Pain Medicine Department Santa Maria Maddalena Hospital  Occhiobello Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13013-017-0121-3"},{"key":"e_1_2_7_3_1","unstructured":"SluijterME.Pain in Europe Barcelona. 2nd Annual Congress of the European Federation of IASP Chapters; 1997. Non\u2010thermal Radiofrequency procedures in the treatment spinal pain."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2014\/17\/477"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S55749"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000766"},{"key":"e_1_2_7_7_1","first-page":"374","article-title":"Investigating the effects of pulsed radiofrequency on dorsal root ganglion in chronic lumbar radicular pain patients: is it not important that we ask the right question, the right way, on an appropriate sample of patients?","volume":"17","author":"Shanthanna H","year":"2016","journal-title":"Pain Med."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2006.00148.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnp.2016.02.003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000492"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.880"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/B978-0-443-06647-4.50021-5","volume-title":"H\u2010Reflex and F\u2010Response Studies. From: Electrodiagnosis in Clinical Neurology","author":"Fisher MA","year":"2005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00230098"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S164414"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12028"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200501000-00021"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.03.001"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.02.012"},{"key":"e_1_2_7_19_1","first-page":"1594","article-title":"Recovery of H\u2010Reflex with transforaminal epidural steroid injection in S1 radiculopathy","volume":"18","author":"Gunduz OH","year":"2017","journal-title":"Pain Med."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000063"},{"key":"e_1_2_7_21_1","first-page":"297","article-title":"Inhibition of somatosensory evoked potentials during spinal cord stimulation and its possible role in the comprehension of antalgic mechanisms of neurostimulation for neuropathic pain","volume":"78","author":"Buonocore M","year":"2012","journal-title":"Minerva Anestesiol."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200211150-00034"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005765"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.18.030195.001535"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2005.00076.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1533-2500.2002.02023.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019716"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.1998.t01-1-00392.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.69.3.703"},{"key":"e_1_2_7_30_1","first-page":"375","article-title":"Reply to: is it not important that we ask the right question, the right way, on an appropriate sample of patients?","volume":"17","author":"Koh W","year":"2016","journal-title":"Pain Med."},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2007.05.046"},{"key":"e_1_2_7_32_1","first-page":"1594","article-title":"Recovery of H\u2010reflex with transforaminal epidural steroid injection in S1 radiculopathy","volume":"18","author":"Osman HG","year":"2017","journal-title":"Pain Med."},{"key":"e_1_2_7_33_1","unstructured":"StretanskiMF.H\u2010reflex latency and nerve root tension sign correlation in fluoroscopically guided contrast\u2010confirmed translaminar lumbar epidural steroid\u2010bupivacaine injections."},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12227"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.12955","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/papr.12955","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.12955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T13:07:46Z","timestamp":1693573666000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.12955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,25]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/papr.12955"],"URL":"https:\/\/doi.org\/10.1111\/papr.12955","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"type":"print","value":"1530-7085"},{"type":"electronic","value":"1533-2500"}],"subject":[],"published":{"date-parts":[[2020,10,25]]},"assertion":[{"value":"2020-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}