{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:05:29Z","timestamp":1791975929951,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01\u2010EY026972"],"award-info":[{"award-number":["R01\u2010EY026972"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate how ocular, oral, and bodily neuropathic pain symptoms, which characterize small fiber neuropathies, are associated with Sj\u00f6gren\u2019s syndrome (SS) classification based on the American College of Rheumatology\/European League Against Rheumatism (ACR\/EULAR) criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants enrolled in the Sj\u00f6gren\u2019s International Collaborative Clinical Alliance (SICCA) registry had ocular, rheumatologic, oral, and labial salivary gland (LSG) biopsy examinations, blood and saliva samples collected, and completed questionnaires at baseline. We used mixed effects modeling with age, country, gender, and depression being fixed effects and study site, a random effect, to determine if neuropathic pain indicators (assessed via questionnaires) were associated with being classified as SS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3,514 participants were enrolled into SICCA, with 1,541 (52.9%) meeting the 2016 ACR\/EULAR classification criteria for SS. There was a negative association between being classified as SS and experiencing bodily neuropathic pain features of needle\u2010like pain, prickling\/tingling sensation, ocular neuropathic pain of constant burning, and constant light sensitivity, and having a presumptive diagnosis of neuropathic oral pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found that those classified as SS had lower scores\/reports of painful neuropathies compared with those classified as non\u2010SS. Non\u2010SS patients with dry eye disease or symptoms could benefit from pain assessment as they may experience painful small\u2010fiber neuropathies (SFNs). Pain questionnaires may help identify pain associated with SFNs in patients with SS and non\u2010SS dry eye. Future studies would be helpful to correlate self\u2010reports of pain to objective measures of SFNs in those with SS, non\u2010SS dry eye, and healthy controls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.13000","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T23:02:39Z","timestamp":1612393359000},"page":"630-637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Neuropathic Pain in the Eyes, Body, and Mouth: Insights from the Sj\u00f6gren\u2019s International Collaborative Clinical Alliance"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2454-5016","authenticated-orcid":false,"given":"Elisabeth A.","family":"Gebreegziabher","sequence":"first","affiliation":[{"name":"Francis I. Proctor Foundation University of California, San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vatinee Y.","family":"Bunya","sequence":"additional","affiliation":[{"name":"Scheie Eye Institute Department of Ophthalmology University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan N.","family":"Baer","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Jordan","sequence":"additional","affiliation":[{"name":"Department of Orofacial Sciences School of Dentistry University of California, San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esen K.","family":"Akpek","sequence":"additional","affiliation":[{"name":"Ocular Surface Diseases and Dry Eye Clinic The Wilmer Eye Institute Johns Hopkins University Baltimore Maryland USA"},{"name":"The Johns Hopkins Jerome L. Greene Sj\u00f6gren's Syndrome Center Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Rose\u2010Nussbaumer","sequence":"additional","affiliation":[{"name":"Francis I. Proctor Foundation University of California, San Francisco San Francisco California USA"},{"name":"Kaiser Permanente Redwood City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey A.","family":"Criswell","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California, San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline H.","family":"Shiboski","sequence":"additional","affiliation":[{"name":"Department of Orofacial Sciences School of Dentistry University of California, San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Lietman","sequence":"additional","affiliation":[{"name":"Francis I. Proctor Foundation University of California, San Francisco San Francisco California USA"},{"name":"Department of Ophthalmology University of California, San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Francis I. Proctor Foundation University of California, San Francisco San Francisco California USA"},{"name":"Department of Ophthalmology University of California, San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1384.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optom.2016.06.002"},{"key":"e_1_2_9_4_1","first-page":"1333","article-title":"[Sjogren's syndrome\u2010associated neuropathy]","volume":"65","author":"Koike H","year":"2013","journal-title":"Brain and nerve = Shinkei kenkyu no shinpo"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000024"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2015.05.002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-011-0181-7"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn093"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000177330.35147.70"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.97"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23859"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20062"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bacf05"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000535"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39859"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12763"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2014.10.2.108"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10181"},{"issue":"10","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.revmed.2010.07.022","article-title":"Neuropathie des petites fibres: approche diagnostique et traitement, et place deson association au syndrome de Gougerot\u2010Sj\u00f6gren primaire Small fibre neuropathy: Diagnostic approach and therapeutic issues, and its association with primary Sj\u00f6gren\u2019s syndrome","volume":"31","author":"D. S\u00e8ne F\u2010JA","year":"2010","journal-title":"La revue de m\u00e9decine interne"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13508"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2018-000885"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40674-017-0076-9"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh605"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004150170135"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23762"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0b013e3181ebe59f"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.110619"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000566"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303838"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep22480"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.13000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/papr.13000","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.13000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T01:27:52Z","timestamp":1693358872000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.13000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,17]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/papr.13000"],"URL":"https:\/\/doi.org\/10.1111\/papr.13000","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,17]]},"assertion":[{"value":"2020-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}