{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:52:29Z","timestamp":1747187549838,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Selective nerve root block (SNRB) was shown to effectively control radiating pain and reduce the need for surgical intervention. However, repetitive injections may trigger corticosteroid\u2010induced side effects (hypercorticism, hyperglycemia, or fluid retention). This study aims to compare the potency of hyaluronic acid\u2010carboxymethylcellulose (HA\u2010CMC) solution versus that of corticosteroids regarding lower leg radiating pain (LLRP) improvement and functional outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among 128 patients, 44 patients who complain about having LLRP due to lumbar spinal stenosis and do not have neurological symptoms requiring surgery were enrolled for this study. Group A with 22 patients injected with cocktail A (local anesthetics and corticosteroid) and group B with 22 patients injected with cocktail B (local anesthetics and HA\u2010CMC). Outcome measures were the visual analog scale (VAS), Oswestry Disability Index (ODI), and short form\u201036 (SF\u201036). All patients were asked to fill in the questionnaires during the follow\u2010up assessment period at 3\u00a0days, 7\u00a0days, 2\u00a0weeks, 6\u00a0weeks, and 12\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all time periods, there were no statistical differences between the two groups for VAS scores and VAS improvement over time, ODI scores and ODI improvement over time, and SF\u201036 PCS scores and SF\u201036 mental component score scores. Additionally, the 95% confidence interval of the difference in VAS score improvement between the 2 groups in all time periods was within VAS 5.0, which is the minimum clinically relevant difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Considering the adverse effects of corticosteroids, and the similar LLRP improvements, functional outcome, and quality of life, the HA\u2010CMC solution may be an alternative option to corticosteroid in SNRB.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.13018","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T21:37:13Z","timestamp":1618868233000},"page":"785-793","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of the effects of corticosteroid and hyaluronic acid\u2010carboxymethylcellulose solution on selective nerve root block for lumbar radiculopathy: A prospective, double\u2010blind, randomized controlled clinical trial"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3527-9251","authenticated-orcid":false,"given":"Sangbong","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery College of Medicine Daegu Catholic University Daegu City Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ChungMu","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery College of Medicine Daegu Catholic University Daegu City Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery College of Medicine Daegu Catholic University Daegu City Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junho","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery College of Medicine Daegu Catholic University Daegu City Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199006000-00020"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199709150-00012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2213001635"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.E.00278"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4184\/asj.2015.9.1.83"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2018.10.011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.1.SPINE11842"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2192568217728724"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1267109"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199504000-00021"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200006000-00018"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(00)90104-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.87B3.15338"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2013\/16\/321"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001158"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4055\/cios.2019.11.2.183"},{"key":"e_1_2_8_18_1","unstructured":"Food Drug Administration.FDA drug safety communication: FDA requires label changes to warn of rare but serious neurologic problems after epidural corticosteroid injections for pain2014.http:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm394280.htm. 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