{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:09:30Z","timestamp":1760609370862,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T00:00:00Z","timestamp":1625356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Succinylcholine is a preferred muscle relaxant for rapid sequence intubation. Postoperative myalgia (POM) is one of its commonest adverse effects with unknown pathogenesis. Various modalities were examined to reduce POM. We hypothesized that duloxetine may reduce the incidence and severity of fasciculation or succinylcholine\u2010induced POM in outpatient surgeries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized double\u2010blinded trial involved controlled 70 adult participants scheduled for elective direct microlaryngoscopic surgeries. Before induction of general anesthesia by 2\u00a0h, 35 patients received duloxetine 30\u00a0mg orally (group D) and 35 patients received similar oral starch placebo capsules (group C). Fasciculations, POM, sedation score, time to first rescue analgesia, total analgesic consumption 24\u00a0h after surgery, patients\u2019 satisfaction, and adverse effects were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Incidence of fasciculation was 77.1% and 94.3% in groups D and C (<jats:italic>p<\/jats:italic> value = 0.04), whereas its severity was not significant between groups (<jats:italic>p<\/jats:italic> value = 0.09). Incidence and severity of POM were significantly lower in group D (<jats:italic>p<\/jats:italic> values = 0.004 and 0.021). Positive correlation was recorded between fasciculations and POM scores (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.732 and <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001). Time required for first analgesia was prolonged in group D (<jats:italic>p<\/jats:italic> value\u00a0&lt;\u00a00.001) with less total analgesic consumption (<jats:italic>p<\/jats:italic> value\u00a0=\u00a00.039). The potassium and creatine kinase levels showed significant differences between both groups after 30\u00a0min and 24\u00a0h, respectively (<jats:italic>p<\/jats:italic> value\u00a0&lt;\u00a00.05). Sedation scores and patients\u2019 satisfaction were better in duloxetine group (<jats:italic>p<\/jats:italic> value\u00a0&lt;\u00a00.05) with no severe complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preoperative oral duloxetine 30\u00a0mg administration decreased incidence and severity of succinylcholine\u2010related muscle POM and fasciculations. It was also effective in reducing postoperative rescue analgesic requirement with better patients\u2019 satisfaction and no serious adverse effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.13050","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T08:29:00Z","timestamp":1624004940000},"page":"57-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of duloxetine on succinylcholine\u2010induced postoperative myalgia after direct microlaryngoscopic surgeries: Randomized controlled double\u2010blind study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3500-7339","authenticated-orcid":false,"given":"Mohamed F.","family":"Mostafa","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Intensive Care Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama","family":"Ali Ibraheim","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed K.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Public Health Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reham A. E.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Unit of Phoniatric Otorhinolaryngology Department Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ragaa","family":"Herdan","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,4]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"2027","article-title":"Evaluation of prophylactic effect of remifentanil on succinylcholine\u2010induced myalgia in humans","volume":"13","author":"Nasseri K","year":"2014","journal-title":"TJPR"},{"issue":"1","key":"e_1_2_9_3_1","first-page":"183","article-title":"Succinylcholine use in adult anesthesia\u2013a multinational questionnaire survey","volume":"35","author":"Karanovi N","year":"2011","journal-title":"Coll Antropol"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0022-3859.93248"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2003.00052.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0022-3859.128801"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm058225d"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.03.029"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181e89a93"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.118.250969"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198707000-00014"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199809000-00044"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5920.656"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2929.2004.02012.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.109728"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2000.055002144.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9185.92451"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000971"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2019-100687"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000471"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq158"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjan.2016.01.003"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881108091588"},{"key":"e_1_2_9_25_1","first-page":"57","article-title":"Effect of perioperative duloxetine on postoperative pain relief following anterior cervical microdiscectomy and fusion. A pilot study","volume":"4","author":"Saoud A","year":"2013","journal-title":"World Spinal Column J"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2018_164"},{"issue":"2","key":"e_1_2_9_27_1","first-page":"105","article-title":"The effect of succinylcholine on serum potassium levels in patients with intra\u2010abdominal infection","volume":"47","author":"Anjali Soodan TK","year":"2003","journal-title":"Indian J Anaesth"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s0054010050239"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31822079fa"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199005000-00002"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.13050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/papr.13050","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.13050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T20:53:23Z","timestamp":1692996803000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.13050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,4]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/papr.13050"],"URL":"https:\/\/doi.org\/10.1111\/papr.13050","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"type":"print","value":"1530-7085"},{"type":"electronic","value":"1533-2500"}],"subject":[],"published":{"date-parts":[[2021,7,4]]},"assertion":[{"value":"2021-07-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}