{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:19:36Z","timestamp":1792009176827,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Spinal cord stimulation (SCS) is a well\u2010established treatment for chronic intractable pain of the trunk and\/or limbs; however, low back pain (LBP) is difficult to treat using traditional SCS. Differential Target Multiplexed spinal cord stimulation (DTM SCS) is an advanced approach inspired from animal studies demonstrating improved pain\u2010related behavior and pain\u2010relevant biological processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The purpose of this study was to compare the effectiveness of DTM SCS and traditional SCS in treating chronic LBP and leg pain (LP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, postmarket randomized controlled trial compared DTM SCS to traditional SCS in patients with chronic LBP and LP. Primary end point was LBP responder rate (percentage of subjects with \u2265\u00a050% relief) at 3\u00a0months. Noninferiority and superiority were assessed. Other outcomes included mean change in back and leg pain, responder rates, disability, global health, satisfaction, and safety profile throughout the 12\u2010month follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred twenty\u2010eight subjects were randomized across 12 centers (67 DTM SCS and 61 traditional SCS). Of the 94 patients implanted, 46 subjects in each group completed the 3\u2010month assessment. LBP responder rate of 80.1% with DTM SCS was superior to 51.2% with traditional SCS (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0010). Mean LBP reduction (5.36\u00a0cm) with DTM SCS was greater than reduction (3.37\u00a0cm) with traditional SCS (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001). These results were sustained at 6\u00a0months and 12\u00a0months. Safety profiles were similar between treatment groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Superiority of DTM SCS compared with traditional SCS for chronic LBP was demonstrated. Clinical improvements provided by DTM SCS were sustained over 12\u00a0months and are expected to significantly impact the management of chronic LBP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/papr.13066","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T07:08:33Z","timestamp":1628320113000},"page":"912-923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":134,"title":["Twelve\u2010Month results from multicenter, open\u2010label, randomized controlled clinical trial comparing differential target multiplexed spinal cord stimulation and traditional spinal cord stimulation in subjects with chronic intractable back pain and leg pain"],"prefix":"10.1111","volume":"21","author":[{"given":"Michael","family":"Fishman","sequence":"first","affiliation":[{"name":"Center for Interventional Pain and Spine Exton Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold","family":"Cordner","sequence":"additional","affiliation":[{"name":"Florida Pain Management Associates Sebastian Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Justiz","sequence":"additional","affiliation":[{"name":"Oklahoma Pain Physicians Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2147-3523","authenticated-orcid":false,"given":"David","family":"Provenzano","sequence":"additional","affiliation":[{"name":"Pain Diagnostics and Interventional Care, LLC Sewickly Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Merrell","sequence":"additional","affiliation":[{"name":"Coastal Carolina Research Center Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binit","family":"Shah","sequence":"additional","affiliation":[{"name":"Carolinas Research Institute PLLC Huntersville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Naranjo","sequence":"additional","affiliation":[{"name":"South Florida Clinical Research South Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Interventional Pain and Spine Exton Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Calodney","sequence":"additional","affiliation":[{"name":"Precision Spine Care Tyler Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Carlson","sequence":"additional","affiliation":[{"name":"Hawaii Pain and Spine Kailua Hawaii USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bundschu","sequence":"additional","affiliation":[{"name":"Coastal Orthopedics Bradenton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahendra","family":"Sanapati","sequence":"additional","affiliation":[{"name":"Global Scientific Innovations, LLC Evansville Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipul","family":"Mangal","sequence":"additional","affiliation":[{"name":"National Spine and Pain Center Oxon Hill Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3568-7151","authenticated-orcid":false,"given":"Ricardo","family":"Vallejo","sequence":"additional","affiliation":[{"name":"National Spine and Pain Centers Bloomington Illinois 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