{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:32:08Z","timestamp":1781004728665,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T00:00:00Z","timestamp":1636848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Spinal cord stimulation (SCS) is being increasingly used in non\u2010surgical intractable low back pain. This study was designed to evaluate the efficacy of high\u2010dose (HD) SCS utilizing sub\u2010perception stimulation with higher frequency and pulse width in non\u2010surgical predominant low\u2010back pain population at 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 20 patients were recruited (280 screened between March 2017 and July 2018) to undergo percutaneous fluoroscopic\u2010guided SCS (Medtronic 8 contact standard leads and Restore<jats:sup>R<\/jats:sup> IPG), with T8 and T9 midline anatomical parallel placement. Sixteen patients completed 12\u00a0months follow\u2010up (500\u00a0Hz frequency, 500\u00a0\u03bcs pulse width, and 25% pulse density). Differences in patients\u2019 clinical outcome (NRS back, NRS leg, ODI, PGIC, and PSQ) and medication usage (MQS) at 1, 3, and 12\u00a0months from the baseline were assessed using non\u2010parametric Wilcoxon paired test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean NRS scores for back pain (baseline 7.53) improved significantly at 1, 3, and 12\u00a0months; 2.78 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), 4.45 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), and 3.85 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), respectively. The mean NRS score for leg pain (baseline 6.09) improved significantly at 1 and 3\u00a0months; 1.86 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and 3.13 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.010), respectively. Mean NRS for leg pain at 12\u00a0months was 3.85 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.057). ODI and sleep demonstrated significant improvement as there was consistent improvement in medication particularly opioid usage (MQS) at 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates that anatomical placement of leads with sub\u2010perception HD stimulation could provide effective pain relief in patients who are not candidates for spinal surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.13087","type":"journal-article","created":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T17:41:30Z","timestamp":1635097290000},"page":"233-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effectiveness of high dose spinal cord stimulation for non\u2010surgical intractable lumbar radiculopathy \u2010 HIDENS Study"],"prefix":"10.1111","volume":"22","author":[{"given":"Vivek","family":"Mehta","sequence":"first","affiliation":[{"name":"Pain Research 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