{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:20:20Z","timestamp":1787818820404,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017636","name":"Pfizer\u2019s Centers for Therapeutic Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study assessed associations between severity of, and prescription medication use for, chronic low back pain (CLBP) and health\u2010related quality of life, health status, work productivity, and healthcare resource utilization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study utilized SF\u201012, EQ\u20105D\u20105L, and work productivity and activity impairment (WPAI) questionnaires, and visits to healthcare providers among adults with self\u2010reported CLBP participating in the National Health and Wellness Survey in Germany, France, UK, Italy, and Spain. Respondents were stratified into four groups according to pain severity (mild or moderate\/severe) and prescription medication use (Rx\u2010treated or Rx\u2010untreated). Differences between groups were estimated using generalized linear models controlling for sociodemographics and health characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 2086 respondents with CLBP, 683 had mild pain (276 Rx\u2010untreated, 407 Rx\u2010treated) and 1403 had moderate\/severe pain (781 Rx\u2010untreated, 622 Rx\u2010treated). Respondents with moderate\/severe pain had significantly worse health\u2010related quality of life (SF\u201012v2 physical component summary), health status (EQ\u20105D\u20105L), and both absenteeism and presenteeism compared with those with mild pain, including Rx\u2010untreated (moderate\/severe pain Rx\u2010untreated vs. mild pain Rx\u2010untreated,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u2264\u00a00.05) and Rx\u2010treated (moderate\/severe pain Rx\u2010treated vs. mild pain Rx\u2010treated,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u2264\u00a00.05) groups. Significantly more visits to healthcare providers in the last 6\u00a0months were reported for moderate\/severe pain compared with mild pain for Rx\u2010treated (least squares mean 13.01 vs. 10.93,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.012) but not Rx\u2010untreated (8.72 vs. 7.61,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.072) groups. Health\u2010related quality of life (SF\u201012v2 physical component summary) and health status (EQ\u20105D\u20105L), as well as absenteeism and presenteeism, were significantly worse, and healthcare utilization was significantly higher, in the moderate\/severe pain Rx\u2010treated group compared with all other groups (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u2264\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Greater severity of CLBP was associated with worse health\u2010related quality of life, health status, and absenteeism and presenteeism, irrespective of prescription medication use. Greater severity of CLBP was associated with increased healthcare utilization in prescription medication users.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/papr.13093","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T08:37:15Z","timestamp":1636965435000},"page":"359-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Burden of chronic low back pain: Association with pain severity and prescription medication use in five large European countries"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0509-1592","authenticated-orcid":false,"given":"Serge","family":"Perrot","sequence":"first","affiliation":[{"name":"Centre d'Evaluation et Traitement de la Douleur INSERM U987 H\u00f4pital Cochin Universit\u00e9 de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Doane","sequence":"additional","affiliation":[{"name":"Kantar Horsham Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5134-037X","authenticated-orcid":false,"given":"Dena H.","family":"Jaffe","sequence":"additional","affiliation":[{"name":"Kantar Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Dragon","sequence":"additional","affiliation":[{"name":"Global Medical Affairs Pfizer Ltd Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Abraham","sequence":"additional","affiliation":[{"name":"Patient and Health Impact Pfizer Ltd Tadworth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Viktrup","sequence":"additional","affiliation":[{"name":"Global Product Development Eli Lilly and Company Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Bushmakin","sequence":"additional","affiliation":[{"name":"Pfizer Inc. Groton Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph C.","family":"Cappelleri","sequence":"additional","affiliation":[{"name":"Pfizer Inc. Groton Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip G.","family":"Conaghan","sequence":"additional","affiliation":[{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds Leeds UK"},{"name":"NIHR Leeds Biomedical Research Centre Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70281-7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001389"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30480-X"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001097"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-8910.2015049005874"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-018-5673-2"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001390"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.344"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200203010-00017"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34347"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32279-7"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2019.1565992"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2458"},{"key":"e_1_2_11_15_1","unstructured":"National Institute for Health and Care Excellence.Low back pain and sciatica in over 16s: assessment and management. 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