{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:47:17Z","timestamp":1792374437621,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Celiac plexus neurolysis (CPN) has been developed as adjunctive therapy to medical management (MM) of abdominal pain associated with unresectable pancreatic cancer. We aimed to conduct a systematic review and meta\u2010analysis to obtain updated and\u00a0more accurate evidence on the efficacy of additional types of CPN, including endoscopic ultrasound\u2010guided CPN (EUS\u2010CPN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>On March 16, 2021, we performed searches of PubMed, Web of Science, and CENTRAL for original randomized controlled trials (RCTs). We defined the primary outcome as a standardized pain intensity score with a range of 0\u201310, and evaluated the mean difference between the CPN\u2009+\u2009MM and MM groups at 4, 8, and 12\u2009weeks after the initiation of treatment. We used a random\u2010effects model to synthesize the mean differences across RCTs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We selected 10 RCTs involving 646 individuals. The synthesized mean difference in the pain intensity score between the CPN\u2009+\u2009MM and MM groups was \u22120.58 (95% confidence interval [CI]: \u22121.09 to \u22120.07) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.034) in favor of CPN\u2009+\u2009MM at 4\u2009weeks, \u22120.46 (95%CI: \u22121.00 to 0.08) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.081) at 8\u2009weeks, and\u2009\u2212\u20091.35 (95%CI: \u22123.61 to 0.92) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.17) at 12\u2009weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This updated meta\u2010analysis of CPN demonstrates its efficacy for managing abdominal pain at 4\u2009weeks. Although there are various limitations, when abdominal pain in patients with unresectable pancreatic cancer is poorly controlled with MM alone, CPN should be an option even if the duration of effect is short\u2010lived, taking into account the absence of serious adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/papr.13143","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T07:40:25Z","timestamp":1656056425000},"page":"652-661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Systematic review and meta\u2010analysis of celiac plexus neurolysis for abdominal pain associated with unresectable pancreatic cancer"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6291-1235","authenticated-orcid":false,"given":"Muneyori","family":"Okita","sequence":"first","affiliation":[{"name":"Department of Biostatistics Nagoya University 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