{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T09:38:49Z","timestamp":1786786729700,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Dorsal root ganglion stimulation (DRG\u2010S) has recently emerged as a novel therapy in neuromodulation that demonstrated a higher rate of success than spinal cord stimulation (SCS) in a prospective, head\u2010to\u2010head randomized comparative trial to treat complex regional pain syndrome (CRPS) and causalgia. In contrast to SCS, DRG\u2010S also shows promise in treating conditions that are not purely neuropathic such as axial low back pain, which has a prominent nociplastic pain component. It is not known to what extent the effectiveness of DRG\u2010S for such indications is due to effective treatment of the neuropathic pain component versus the effects of DRG\u2010S on mechanical pain. Although rarely studied, reporting outcomes of DRG\u2010S to treat predominantly mechanical\/nociceptive pain may help point toward expanding the utility of this therapy. Here, we present five cases of refractory mechanical pain treated with DRG\u2010S.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of all patients who underwent a successful DRG\u2010S trial and implant between September 2017 and September 2021 at our institute was performed. Patients who had intractable joint pain without strong evidence of neuropathic pain were included in this case series. The Budapest criteria for CRPS, the Douleur Neuropathique 4 Questions (DN4) survey, or a definable nerve injury were used to determine the presence of neuropathic pain. Baseline assessments for pain (Numeric Rating Scale [NRS]), function (Oswestry Disability Index [ODI]), quality of life (EuroQol\u20105 Dimension [EQ\u20105D]), and other applicable joint surveys were extracted from pre\u2010trial baseline and follow\u2010up appointments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five patients were identified and included. Patient diagnoses consisted of refractory joint pain of the hip, knee, or ankle. Mean NRS pain scores improved by 74% from 9.2 at baseline to 2.4 at the last follow\u2010up (mean\u00a0=\u00a028\u2009months post\u2010implant). From baseline to the last follow\u2010up, mean ODI scores improved by 65% from 66 to 23 and EQ\u20105D scores more than doubled from an average of 0.371 to 0.797.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This clinical report illustrates the potential utility DRG\u2010S has in treating pain that clinically presents as predominantly refractory mechanical joint pain without a significant neuropathic component. The physiological reasons for our observations may be that DRG\u2010S is able to directly influence the conduction of nociceptive signaling at the DRG and within the spinal cord. Further investigations are warranted to determine if DRG\u2010S is a potential treatment option for chronic mechanical pain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.13180","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T12:49:46Z","timestamp":1667652586000},"page":"317-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dorsal root ganglion stimulation for the treatment of joint pain with predominantly nociceptive characteristics: A case series"],"prefix":"10.1111","volume":"23","author":[{"given":"Kenneth B.","family":"Chapman","sequence":"first","affiliation":[{"name":"Spine &amp; Pain Institute of New York New York New York USA"},{"name":"Department of Anesthesiology New York University Langone Medical Center New York New York USA"},{"name":"Departement of Anesthesiology Zucker School of Medicine at Hofstra\/Northwell Hempstead New York USA"},{"name":"Department of 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