{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:52:56Z","timestamp":1791237176620,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Traditional spinal cord stimulation (t\u2010SCS) has been used to treat chronic pain for over 50\u2009years. However, up to 30% of patients undergo explant, with the main indication being loss of efficacy (LoE), and few alternative treatment options exist for these patients. Strategies to mitigate LoE commonly include conversion to another type of SCS (termed \u2018salvage\u2019 or \u2018rescue\u2019). This review summarizes the existing literature concerning the efficacy and safety of 10\u00a0kHz SCS as a salvage therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed, the Cochrane Library, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>, and other sources between January 2009 and April 2021. Records were retained if the authors reported clinical outcomes with a minimum of \u2265\u20093\u00a0months of follow\u2010up in patients implanted with a Senza\u00ae 10\u00a0kHz SCS system in an effort to treat t\u2010SCS\u00a0LoE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten articles were eligible for inclusion, reporting 3 prospective studies and 7 retrospective reviews. In the single study that salvaged patients without a repeat trial prior to surgery, 81% of patients were responders (\u2265\u200950% pain relief from baseline), with mean pain relief of 60%. Among repeat\u2010trial studies, the responder rate ranged from 46% to 80%, and mean pain relief from 47% to 68%. No unanticipated therapy\u2010related safety issues were reported among the included articles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preliminary data suggest that chronic back and\/or leg pain patients with t\u2010SCS LoE can experience improved and durable pain relief after conversion to 10\u00a0kHz SCS. However, additional research is needed to define predictors of success and establish whether salvage without a repeat trial is a viable conversion method.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.13184","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T13:43:43Z","timestamp":1669038223000},"page":"301-312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["High\u2010frequency (10\u00a0k<scp>H<\/scp>z) spinal cord stimulation (<scp>SCS<\/scp>) as a salvage therapy for failed traditional <scp>SCS<\/scp>: A narrative review of the available evidence"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2147-3523","authenticated-orcid":false,"given":"David Anthony","family":"Provenzano","sequence":"first","affiliation":[{"name":"Pain Diagnostics and Interventional Care  Sewickley Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Park","sequence":"additional","affiliation":[{"name":"Lancashire Teaching Hospitals  Preston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Edgar","sequence":"additional","affiliation":[{"name":"Commexus Ltd  Dunblane UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Bovinet","sequence":"additional","affiliation":[{"name":"The Spine Center of SE Georgia  Brunswick Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Tate","sequence":"additional","affiliation":[{"name":"Southern Pain and Spine  Jasper Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.13036"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12634"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12312"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12639"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pny245"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12642"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.12.031"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12617"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050312120951369"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13285"},{"issue":"2","key":"e_1_2_11_12_1","first-page":"180","article-title":"Efficacy and safety of 10 kHz spinal cord stimulation for the treatment of chronic pain: a systematic review and narrative synthesis of real\u2010world retrospective studies","volume":"9","author":"Baranidharan G","year":"2021","journal-title":"Biomedicine"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2217\/pmt-2020-0047"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.13280"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1776"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12277"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12294"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S281749"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12898"},{"issue":"3","key":"e_1_2_11_20_1","first-page":"e1","article-title":"Salvage of previously failed SCS using 10 kHz SCS through a \u2018pocket trial\u2019 technique. Abstract from the North American Neuromodulation Society's 23rd Annual Meeting. January 23\u201326, 2020, Las Vegas, NV, USA","volume":"23","author":"Rosenberg W","year":"2020","journal-title":"Neuromodulation"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.720"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj\/2019.19.267"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12739"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.13359"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00349-9"},{"issue":"3","key":"e_1_2_11_26_1","first-page":"e40","article-title":"High frequency SCS 10 kHz as salvage therapy for unsuccessful traditional SCS trials and implants \u2013 presented at the 22nd annual meeting of the north American neuromodulation society","volume":"22","author":"Ghosh P","year":"2019","journal-title":"Neuromodulation"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2020-101681"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.13184","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/papr.13184","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.13184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T16:56:05Z","timestamp":1692377765000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.13184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,8]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/papr.13184"],"URL":"https:\/\/doi.org\/10.1111\/papr.13184","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,8]]},"assertion":[{"value":"2021-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}