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Psychedelics like lysergic acid diethylamide (LSD) and psilocybin, may play a role in the management of chronic pain. Through activation of the serotonin\u20102A (5\u2010HT2A) receptor, several neurophysiological responses result in the disruption of functional connections in brain regions associated with chronic pain. Healthy reconnections can be made through neuroplastic effects, resulting in sustained pain relief. However, this process is not fully understood, and evidence of efficacy is limited and of low quality. In cancer and palliative related pain, the analgesic potential of psychedelics was established decades ago, and the current literature shows promising results on efficacy and safety in patients with cancer\u2010related psychological distress. In other areas, patients suffering from severe headache disorders like migraine and cluster headache who have self\u2010medicated with psychedelics report both acute and prophylactic efficacy of LSD and psilocybin. Randomized control trials are now being conducted to study the effects in cluster headache Furthermore, psychedelics have a generally favorable safety profile especially when compared to other analgesics like opioids. In addition, psychedelics do not have the addictive potential of opioids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Implications<\/jats:title><jats:p>Given the current epidemic use of opioids, and that patients are in desperate need of an alternative treatment, it is important that further research is conducted on the efficacy of psychedelics in chronic pain conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.13203","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T08:10:15Z","timestamp":1672819815000},"page":"447-458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Are psychedelics the answer to chronic pain: A review of current literature"],"prefix":"10.1111","volume":"23","author":[{"given":"Nina I.","family":"Kooijman","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Pain and Palliative Medicine Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9721-9441","authenticated-orcid":false,"given":"Tim","family":"Willegers","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Pain and Palliative Medicine Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Reuser","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Pain and Palliative Medicine Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim M.","family":"Mulleners","sequence":"additional","affiliation":[{"name":"Department of Neurology Canisius\u2010Wilhelmina Hospital  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis","family":"Kramers","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris C. 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