{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:42:27Z","timestamp":1788979347665,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T00:00:00Z","timestamp":1681776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2023,7]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Limited data exist concerning the management of postoperative pain after robotic\u2010assisted surgery. The present study was performed to investigate the efficacy of intrathecal morphine and bupivacaine to treat postoperative pain in adult women undergoing robot\u2010assisted laparoscopic hysterectomy.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The primary outcomes of this study were opioid consumption and pain scores during and after robotic surgery. 96 patients were prospectively enrolled and randomized to a nonspinal group (\n n<\/jats:italic>\n \u2009=\u200948) and a spinal group (\n n<\/jats:italic>\n \u2009=\u200948). The intrathecal regimen consisted of 100\u2009\u03bcg morphine and 15\u2009mg of bupivacaine. The numeric rating scale scores (NRS) were assessed every 15\u2009min in the postoperative care unit (PACU) and pain was treated with iv fentanyl or morphine when NRS was above 5 and orally oxycodone when NRS was 3\u20135. Cumulative iv opioid\u2010consumption and NRS scores were compared.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Intrathecal morphine and bupivacaine resulted in a significantly lower cumulative total iv opioid (morphine equivalents) consumption (9.4\u2009\u00b1\u20093.9 vs. 22.8\u2009\u00b1\u20096.1\u2009mg equivalents). Highest recorded NRS scores in the PACU were also significantly lower in the spinal group (2.0\u2009\u00b1\u20092.6 vs. 5.3\u2009\u00b1\u20093.2).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Intrathecal morphine and bupivacaine to treat postoperative pain after robotic\u2010assisted laparoscopic hysterectomy decrease total opioid consumption and NRS pain scores. This might be of great importance to diminish the rate of other serious disadvantages related to opioids.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/papr.13233","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T02:05:10Z","timestamp":1681869910000},"page":"631-638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Analgesic effects of intrathecal morphine and bupivacaine during robotic\u2010assisted surgery: A prospective randomized controlled study"],"prefix":"10.1111","volume":"23","author":[{"given":"Anders J. E.","family":"Engstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Gynaecology Central Hospital of Karlstad Karlstad Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina A.","family":"Ivarsson","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia & Intensive Care Central Hospital of Karlstad Karlstad Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa","family":"Alderg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia & Intensive Care Central Hospital of Karlstad Karlstad Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-2591","authenticated-orcid":false,"given":"Ragnar N.","family":"Henningsson","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia & Intensive Care Central Hospital of Karlstad Karlstad Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000357"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.03.010"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2020-001646"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13994"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.08.024"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/79.3.369"},{"key":"e_1_2_10_8_1","article-title":"A clinical approach to neuroaxial morphine of the treatment of postoperative pain","volume":"2012","author":"Mugabure Bujedo B","year":"2012","journal-title":"Pain Res Treat"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31828866b3"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu090"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.10.011"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004058"},{"key":"e_1_2_10_13_1","first-page":"1","article-title":"Intrathecal morphine for laparoscopic segmental colonic resection as part of an enhanced recovery protocol","volume":"166","author":"Koning MV","year":"2018","journal-title":"Reg Anesth Pain Med"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.05.061"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2008.05817.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12729"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001488"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-005-1044-x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S144066"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003572"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes028"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-021-00798-4"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.12.019"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.07.057"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000273"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7127"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu221"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.13233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T18:12:10Z","timestamp":1692209530000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.13233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,18]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/papr.13233"],"URL":"https:\/\/doi.org\/10.1111\/papr.13233","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,18]]},"assertion":[{"value":"2022-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}