{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:42Z","timestamp":1787015982581,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2023,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Chemotherapy\u2010induced peripheral neuropathy (CIPN) is a common consequence of cancer treatment that can be persistent and difficult to manage. Dorsal root ganglion stimulation (DRG\u2010S) is a recently introduced but understudied treatment modality. This study explored the effect of DRG\u2010S on pain and symptom burden associated with CIPN.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients with CIPN who underwent a DRG\u2010S trial between January 2017 and August 2022 were identified through chart review after IRB approval was obtained. Demographic data, procedure details, pre\u2010and postoperative scores, including the Numerical Rating Scale (NRS) and Edmonton Symptom Assessment System (ESAS), and duration of follow\u2010up were recorded. Statistical analysis included descriptive statistics and paired\n t<\/jats:italic>\n \u2010tests to compare pre\u2010and postoperative scores.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Nine patients with an even mix of solid and hematologic malignancies underwent DRG\u2010S trial and had a statistically significant decrease in NRS scores, with a mean reduction of 2.3 in their average pain (\n p<\/jats:italic>\n \u2009=\u20090.014), 2.6 in worst pain (\n p<\/jats:italic>\n \u2009=\u20090.023), and 2.1 in least pain (\n p<\/jats:italic>\n \u2009=\u20090.018). Eight patients (88.9%) underwent permanent DRG\u2010S implantation. Mean NRS scores remained lower than preoperative baselines through the first year of follow\u2010up. Statistically significant reductions were noted at 3\u2009months in average (2.1,\n p<\/jats:italic>\n \u2009=\u20090.006) and least pain scores (1.9,\n p<\/jats:italic>\n \u2009=\u20090.045), which further decreased after 6\u201312\u2009months (average: 3.6,\n p<\/jats:italic>\n \u2009=\u20090.049; least: 3.4,\n p<\/jats:italic>\n \u2009=\u20090.023). Only the pain component of ESAS scores showed a significant reduction with DRG\u2010S (2.0,\n p<\/jats:italic>\n \u2009=\u20090.021). All patients endorsed improved sensation, 75% decreased their pain medication usage, and 37.5% reported complete pain relief by 2\u2009years.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Dorsal root ganglion stimulation can be an effective treatment for pain related to CIPN and deserves further investigation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/papr.13259","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T07:09:52Z","timestamp":1685603392000},"page":"793-799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Dorsal root ganglion stimulation for\n chemotherapy\u2010induced<\/scp>\n peripheral neuropathy"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4928-4051","authenticated-orcid":false,"given":"Eliana","family":"Ege","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Briggi","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Mach","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billy K.","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Javed","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine MD Anderson Cancer Center Houston Texas 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